女性灼口综合征的性激素水平检测

Study on Serum Levels of Sex Hormone and Cortisol in the Women with Burning Mouth Syndrome

目的 探讨女性灼口综合征 (BMS)患者体内性激素和皮质激素水平的改变与临床症状之间的关系。方法 采用放射免疫分析方法 ,对 60例女性BMS患者血清中的 8种性激素及皮质激素水平进行测定 ,并以2 0例正常女性对照。结果 BMS组睾酮、雄烯二酮、硫酸脱氢表雄酮均高于对照组 (P <0 .0 1) ;雌二醇、孕酮、泌乳素、卵泡刺激素、黄体生成素无明显变化 (P >0 .0 5 ) ;睾酮 /雌二醇的比值明显升高。结论 睾酮 /雌二醇的比值明显升高表明雄激素的相对升高或者是雌激素的相对减少。提示在临床考虑BMS的治疗方案时可以给患者服用一定量的雌激素以维持睾酮 /雌二醇比值平衡 。

Objective To investigate the serum levels of 8 kinds of sex hormone and cortisol in women with burning mouth syndrome(BMS). Methods The serum levels of 8 kinds of sex hormone and cortisol were measured with radioimmunoassay in the women with BMS, compared with 20 healthy controls. Results It was revealed that the levels of testosterone, androstenedione and dehydroepiandrosterone sulfate were significantly higher in patients than those in the controls ( P < 0.01 );No significant difference was found in the levels of estradiol, progesterone, prolactin, follicle stimulating hormone and luteinizing hormone between the two groups( P > 0.05 ); The level of cortisol was significantly decreased in patients with BMS ( P < 0.05 ); A significant lift of the value of testosterone/estradiol in the patients with BMS. Conclusion The study indicates that the relatively higher levels of the value of testosterone / estradiol may be the major reason which causes and that endocrine disorder played an important role in the development of BMS among women, especially those in their climacterium, and indicated efficacy of hormone replacement therapy inpostmenopause women with BMS.