无机银抗菌剂及其塑料制品的抗菌效果和毒性

ANTIMICROBIAL EFFICACY AND TOXICITY OF AN INORGANIC SILVER ANTIMICROBIAL AND ITS PLASTIC PRODUCTS

为了解含银６％（ｇ／ｇ）的无机银抗菌剂的抗菌与破坏ＨＢｓＡｇ效果及毒性，进行了纸片抑菌环测定、载体定性ＨＢｓＡｇ试验与毒性试验。结果，该抗菌剂加水稀释２０、２００、４００倍的混悬液所染滤纸，分别对白色念珠菌、金黄色葡萄球菌、大肠杆菌有抑菌效果；含该剂０．５％（ｇ／ｇ）的塑料洗衣球对大肠杆菌作用 ５ｍｉｎ，有抑菌作用；以该剂１０倍稀释的悬液作用２４ｈ，才可破坏不锈钢片表面ＨＢｓＡｇ抗原性。该抗菌剂对雌、雄小鼠经口ＬＤ５０＞５０００ｍｇ／ｋｇ，对兔皮肤一次性刺激积分为０，微核试验阴性。

In order to know the antimicrobial efficacy. HBsAg-destroying efficacy and toxicity of an inorganic silver antimicrobial containing 6% (g / g) silver, measurement of paper bacterial (fungal) inhibition zone, carrier qualitative HBsAg test and toxicity test were carried out. The results showed that the filter papers carrying the suspension of 20-, 200- and 400- fold di- luted water solution of this antimicrobial had inhibitory effect on Candida albicans, Staphylococcus aureus and Escherichia coli respectively. The plastic washing ball containing 0.5% this antimicrobial (g/ g) with a 5 minute contact time had inhibitory effect on Escherichia coli. The 10-fold diluted suspension of this antimicrobial only with a 24 hour con- tact time could destroy HBsAg antigenicity on surface of stainless steel coupon. The oral LD50 of this antimicrobial in male and female mice was >5 000 mg / kg, the rabbit skin irri- tation score after one application of it was 0 and the micronucleus test was negative.