不同麻醉方法及羊水补充量对手术胎兔成活率的影响

Influence of different anesthesia methods and amniotic fluid volumes compensation on the survival rate of operated fetus

目的 探讨胎兔手术麻醉的合理方法及不同羊水补充量对手术胎兔成活率的影响 .方法 采用硫喷妥钠 iv与84 6合剂 im两种麻醉方法 ,比较其麻醉效果及手术胎兔成活率 ;按胎兔羊水总量的 5 0 .0 % ,70 .0 %和 10 0 .0 %补充手术中损失的羊水 ,比较术后第 5日胎兔成活率 .结果 两种麻醉方法的麻醉效果均满意 ,手术胎兔成活率均达到 83.0 %以上 ;手术胎兔羊水损失量达到总量的 5 0 .0 %时 ,胎兔成活率下降到 6 0 .9% (0 .0 1<P<0 .0 5 ) .羊水损失量低于总量的2 5 .0 %时 ,对胎兔成活率影响不明显 .结论 两种麻醉方法均能满足胎兔手术要求 。

AIM To investigate a reasonable method of anesthesia in the operation of rabbit fetus and the influence of the different volume of amniotic fluid on the survival rate of fetus. METHODS The anesthetic effects and the survival rate of fetus were detected by comparing the vain injection of sodium pentothal with the muscle injection of 846 mixture. The survival rate of fetus was also detected on the 5th day after the operation by compensating amniotic fluid by 50.0%, 75.0% and 100.0% of the total volume respectively. RESULTS The anesthetic effects in the two groups weresatisfactory, and both of the survival rates were more than 83.0% . As half of the total amniotic fluid lost, the survival rate decreased to 61.1% . There was not a significant influence on the survival rate unless the loss of amniotic fluid was more than 25.0%. CONCLUSION Either the vain injection of sodium pentothal or the muscle injection of 846 mixture can be used in the research of operation on fetal rabbits. The survival rate of operated fetus can be improved by compensating the amniotic fluid which was lost during the operation.