摘要
目的:研究左旋氨氯地平治疗高血压合并心房颤动的临床效果。方法入选2005年7月-2013年7月在我院心内科诊疗的610例高血压合并阵发性心房颤动患者,随机分为治疗组与对照组,每组305例,其中治疗组予以左旋氨氯地平,2.5-10.0 mg/ d;对照组予以缬沙坦片,80-160 mg/ d。治疗1年后,检测分析两组的收缩压(SBP)、舒张压(DBP)、Pd、左房横径(LAD)、超敏 C 反应蛋白(hs-CRP)及脑钠肽(BNP)水平以及房颤复发率。结果治疗1年后随访发现,两组的 SBP、DBP、Pd、LAD、hs-CRP 及 BNP 水平均较治疗前显著下降(P ﹤0.05),而两组的 SBP、DBP、Pd、LAD、hs-CRP 及 BNP 水平之间均无统计学差异(P ﹥0.05);缬沙坦组房颤复发率为28.85%(88/305),左旋氨氯地平组为31.15%(95/305),两组间房颤复发率相比较无统计学差异(P ﹥0.05)。结论对于高血压合并阵发性心房颤动患者,左旋氨氯地平可以很好地降压和防治房颤,降低 LAD、hs-CRP 和 BNP 水平,其效果与缬沙坦类似。
Objective To explore the clinical effect of L-amlodipine on atrial fibrillation complicated with hypertension. Methods 610 cases with atrial fibrillation complicated with hypertension hospitalized in the period from July,2005 to July,2013 were randomly divided into 2 groups:treatment group and control group,305 cases in each;L-amlodipine 2. 5 to 10. 0 mg daily was administrated to cases in treatment group,while valsartan 80 to 160 mg daily to cases in control group;the course lasted for 1 year;the levels of SBP,DBP,Pd,LAD,hs-CRP,BNP and reoccurrence of atrial fibrillation in both groups were observed after the treatment. Results The levels of SBP,DBP,Pd,LAD,hs-CRP and BNP in both groups decreased obviously after treatment compared with those before treatment( P ﹤ 0. 05),while there existed no difference of statistical significance between the 2 groups( P ﹥ 0. 05);the reoccurrence of atrial fibrillation was 28. 85%(88 / 305)in control group and 31. 15%(95 / 305)in treatment group,the difference in reoccurrence of atrial fibrillation between the 2 groups was of no statistical significance(P ﹥ 0. 05). Conclusions L-amlodipine is effective in decreasing blood pressure and preventing reoccurrence of atrial fibrillation in patients with atrial fibrillation complicated with hypertension,and it can decrease the levels of LAD,hs-CRP and BNP;it has the similar effect to valsartan.
出处
《西南国防医药》
CAS
2014年第7期718-721,共4页
Medical Journal of National Defending Forces in Southwest China
关键词
左旋氨氯地平
缬沙坦
高血压
心房颤动
疗效
复发率
L-amlodipine
valsartan
hypertension
atrial fibrillation
curative effect
reoccurrence