草酸钾溶液(250g/L)急性毒理、皮肤刺激实验的研究

Acute toxicity and acute skin stimulation of 250g/L potassium oxalate solution

目的 :为临床安全应用草酸钾溶液 ( 2 5 0 g/L)治疗牙本质敏感症提供基础依据。 方法 :采用昆明小鼠和大白兔分别进行了急性毒理和急性皮肤刺激实验。结果 :该浓度的草酸钾溶液未影响雌雄小鼠的生长情况 ,皮肤未出现红斑和水肿 ,动物生长状态良好。结论 :2 5 0 g/L草酸钾溶液作为临床局部用药安全、无毒。

?Objective:To study the toxicity of 250 g/L potassium oxalate solution.Methods:Acute toxicity test and acute skin stimulation test were carried out on Kunmin mice and rabbits.Results:Potassium oxalate solution at 250 g/L did not result in death of the mice even it had been administered at the dose of 10 000 mg/kg by stomach filling.The LD 50 was more than 5 475 mg/kg.The solution did not cause skin reaction in rabbits after application.Conclusion:250 g/L potassium oxalate solution is not toxic and not stimulative as a local applied drug.