DTI对儿童及青少年恢复期创伤性胼胝体损伤的应用研究

Research of Magnetic resonance diffusion tensor imaging in children and adolescents with traumatic injury of corpus callosum

目的探讨磁共振弥散张量成像(diffusion tensor imaging,DTI)在儿童及青少年创伤性胼胝体损伤中的应用价值。方法实验组20例,对照组20例,所有患者均在外伤后一个月以后进行检查。常规磁共振检查后,行DTI扫描,分别测量实验组、对照组各感兴趣区的部分各向异性分数(fractional anisorropy,FA)值,用t检验分析各感兴趣区域的FA值,并对实验组的FA值与格拉斯哥预后评分(Glasgow Outcome Scale,GOS)进行相关性分析。结果实验组胼胝体膝部(FA=0.611±0.02)、胼胝体压部(FA=0.608±0.04)的FA值较对照组下降(P<0.05),实验组胼胝体压部的FA值与GOS评分有相关性(P<0.05)。结论 DTI可以应用于恢复期创伤性胼胝体损伤中,FA值可以作为评估患者预后的指标。

Objective To investigate the magnetic resonance diffusion tensor imaging （MR diffusion tensor imaging,DTI） ap plication value in children and adolescents with traumatic injury of corpus callosum. Methods 20 cases in experimental group, 20 cases in the control group,all the patients were in trauma after a month later to check. After conventional MRI, do DTI scan- ning, fractional anisotropy were measured in experiment group and control group, each region of interest （ fractional anisorro- py, FA） value, t test analysis of each region of interest FA, score and experimental group FA and Glasgow outcome （Glasgow Outcome Scale,GOS） the correlation analysis. Results In the experimental group, the genu of the corpus callosum （FA= 0. 611±0.02）, the splenium of the corpus callosum （FA=0. 608±0.04） FA compared with the control group decreased （P〈 0.05） , the experimental group in the splenium of the corpus callosum FA value and GOS score correlated （P〈0.05）. Conclu- sion DTI can be used in the recovery of traumatic injury of corpus callosum,FA value can be used as an indicator to evaluate the prognosis of patients.