NOS抑制剂L-NNA对福尔马林致痛大鼠伤害性行为反应的影响

Effects of nitric oxide synthase inhibitor L-NNA on formalin-induced noiciceptive behavioral response in rats

目的 检测和评价腹腔注射不同剂量一氧化氮合酶抑制剂L NNA对福尔马林致痛大鼠伤害性行为反应的影响。方法 大鼠腹腔注射L NNA 1h后 ,进行福尔马林实验诱导伤害性行为反应 ,观察L NNA的镇痛效应。结果 腹腔注射不同剂量的L NNA(1 0mg/kg,2 0mg/kg ,40mg/kg ,80mg/kg)产生明显的镇痛作用。结论 一氧化氮在伤害性痛觉调制中起重要作用 ,一氧化氮合酶抑制剂L

Objective To examine and analyse the effect of nitric oxide synthase inhibitor L NNA on formalin induced noiciceptive behavioral response in rats. Methods Rats were pretreated with L-NNA.After 1h,we examined the noiciceptive behavioral response evoked by injecting subcutaneously 50μl of 2.5% formalin into the rat right hindfoot.Results We found that injection intraperitoneally of L NNA(10mg/kg,20mg/kg,40mg/kg,80mg/kg) had significant analgesic effect in formalin test rats.Conclusion Nitric oxide plays an important role in pain modulation; non selective NOS inhibitor L NNA has significant analgesic effect.