c-met蛋白与MVD在卵巢肿瘤组织中表达的意义

Expression of c-met and MVD in ovarian tumor

目的 探讨肝细胞生长因子受体c met蛋白在卵巢肿瘤组织中的表达及其与血管形成之间的关系。方法 应用免疫组化SABC法检测 34例卵巢恶性肿瘤、5例卵巢交界性肿瘤和 9例卵巢良性肿瘤组织的c met蛋白的表达及微血管密度 (MVD)。结果 c met在卵巢良性、交界性和恶性肿瘤组织之间的表达有显著性差异 ,且有逐渐增高趋势。在卵巢恶性肿瘤组织中c met表达与MVD数值相关 ,c -met表达与卵巢恶性肿瘤病理分化之间密切相关。结论 HGF/c met可能通过促进血管形成而在卵巢恶性肿瘤的发生。

Objective To explore the expression of c met in ovarian tumors and relationship between c met and angiogenesis. Methods 34 ovarian malignant tumors, 5 ovarian borderline tumors and 9 ovarian benign tumors were collected by using immunohistochemical technique, microvessel density (MVD) and the expression of c met were examined respectively. Results The expression of c met had a significant difference among the specimens of ovarian benign tumors, borderline tumors and malignant tumors ( P <0.01). An upward tendency was shown. In malignant tumors, the expression of c met was significantly correlated with MVD ( P <0.01). The expression of c met was positively correlated with tumor grade( P <0.01). Conclusion The HGF/c met plays an important role in the generation and progress of ovarian carcinoma through stimulating angiogenesis.