布洛芬缓释胶囊的药代动力学研究

Study on the pharmacokinetics of ibuprofen sustained release capsule

目的 研究布洛芬缓释胶囊单剂量及多剂量给药的药代动力学。方法 用HPLC法测定 1 0名受试者口服 60 0mg布洛芬缓释胶囊后的血药浓度 ,经 3P87药动学计算程序处理 ,得药动学参数。结果 单剂量口服后的Cmax为 (2 7.0 5± 4 .94) μg/ml、Tmax为 (4.4± 0 .70 )h、AUC为 (1 70 .51± 35 .89)h·μg/ml。多剂量口服后的Cmax为 (30 .66± 4 .67) μg/ml、Tmax为 (3 .7± 0 .67)h、AUC为 (1 76 .0 8± 1 8.88)h·μg/ml。波动系数为 1 .49。

Objective To study the pharmacokinetics of ibuprofen sustained release capsule after taking single dosage and multiple dosages.Methods The plasma concentrations of 10 subjects were determined by HPLC after oral taking 600mg ibuprofen sustained release capsule. The pharmacokinetic parameters were gotten from 3P87 program.Results The release capsule after taking single dosage and multiple dosages were as follow; C max were (27.05±4.94)μg/ml and (30.66±4.67) μg/ml respectively; T max were (4.4±0.70)h and (3.7±0.67)h respectively; AUC were (170.51±35.89)h·μg/ml and (176.08±18.88) h·μg/ml respectively. The factor of fluctuation was 1.49.Conclusion The ibuprofen sustained release capsule has sustained release effect.