61例胰岛素抵抗综合征患者脂肪肝临床特点分析

Clinical characteristics of fatty livers of 61 patients with the insulin resistance syndrome

目的 :分析胰岛素抵抗综合征患者脂肪肝临床特点。方法 :用B超直方图半定量检测 6 1例胰岛素抵抗综合征患者的脂肪肝 ,分区采集进行比较 ,并与其临床、生化指标进行相关性研究。结果 :胰岛素抵抗综合征患者肝脏B超平均灰阶值在近门脉区高于近胆囊区 (P <0 .0 0 1)。女性患者肝脏B超平均灰阶均值 (AV)高于男性 (P <0 .0 1)。AV与体重指数 (BMI)、腰围 (W)、臀围 (H)呈显著正相关 ,与腰臀比率 (WHR)、胰岛素敏感指数 (ISI)有负相关趋势 ,与高密度脂蛋白胆固醇 (HDL C)呈显著负相关。结论 :胰岛素抵抗综合征患者肝脏脂质分布在近门脉区高于近胆囊区 ;女性患者脂肪肝程度高于男性 ;脂肪肝与胰岛素抵抗综合征患者多种危险因素相关 ,BMI,W ,H和血清HDL

Objective To analyse the clinical characteristics of fatty livers of patients with the insulin resistance syndrome. Methods With echographic histogram, the acoustic intensity(AV) in six different areas of each fatty liver was measured in 61 patients with the insulin resistance syndrome. The relationship between the average value of AV and some clinical or biochemical parameters were analysed. Results There were significant differences in AV between the area near the portal venous and the area near the gall bladder, and between males and females as well. AV was positively related to the body mass ratio (BMI), waist circle (W) and hip circle (H); AV was positively related to the waist hip ratio (WHR) or insulin sensitive index (ISI) in trend; and AV was negatively related to high density lipoprotein cholesterin (HDL C). Conclusion In patients with the insulin resistance syndrome, fatty density of livers is higher near the portal venous than near the gall bladder. The fatty liver is more serious in females than in males. BMI, W, H and serum HDL C levels are useful parameters in evaluating the severity of fatty livers.