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急性白血病患者血浆和脑脊液中可溶性L-选择素测定及意义 被引量：1

Clinical significance of the detection of the sL-selectin level in patients with acute leukemia
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摘要 目的 :探讨急性白血病血浆及脑脊液可溶性L 选择素水平 (sL selectin)与急性白血病发病及病情变化的关系。方法 :用酶联免疫吸附双抗体夹心法 (ELISA)测定 4 0例急性白血病患者的血浆及 2 8例急性淋巴细胞白血病患者的脑脊液中sL selectin ,并分别与正常对照组比较。结果 :初治及难治性急性白血病患者体内的sL selectin水平较缓解者及正常对照者均显著增高 (P <0 .0 0 1)。且sL selectin水平与临床过程有关 ,随着病情缓解和复发 ,sL selectin水平也随之变化。结论 :监测患者血浆和脑脊液sL Objective To study the relationship between the episode and state of acute leukemia and the level of soluble L selectin (sL selectin) in the plasma and cerebrospinal fluid. Methods With a sandwich enzyme linked immunosorbent assay (ELISA), the levels of sL selectin in the plasma of 40 patients with acute leukemia and in the cerebrospinal fluid of 28 patients with acute lymphoblastic leukemia were measured, and compared with 20 controls. Results The levels of sL selectin were significantly higher in the patients with untreated and therapy resistant acute leukemia or leukemia relapse than those in the complete remission patients and the controls (P<0.001). The levels of sL selectin were related to the clinical course of acute leukemia. Conclusion Monitoring the sL selectin level may be useful for evaluating leukemia activity, in particular for the detection of leukemia relapse and meningeal infiltration.
作者 常建华 齐振华 徐敏 彭旭阳
机构地区 中南大学湘雅医院血液科 中南大学湘雅二医院血液科
出处 《湖南医科大学学报》 CSCD 北大核心 2002年第2期151-153,共3页 Bulletin of Hunan Medical University
关键词 急性白血病 血浆 脑脊液 可溶性L-选择素 测定 leukemia,acute soluble L selectin plasma cerebrospinal fluid
分类号 R733.71 [医药卫生—肿瘤]
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参考文献13

  • 1Schleiffenbaum B, Spertini O, Tedder TF. Soluble L-selectin is presentin human plasma at high levels and retains functional activity[J]. J Cell Biol, 1992,119:229-238.
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同被引文献11

  • 1Tedder TF, Penta AC, Levine HB, et al. Expression of the human leukocyte adhension molecule, LAM1. Identity with the TQ1 and Leu-8 differentiation antigens. J Immunol, 1990; 144:532 - 540.
  • 2Stucki A, Rivier AS, Gikic M, et al. Endothelial cell activation by myeloblasts: molecular mechanisms of leukostasis and leukemic cell dissemination. Blood, 2001; 97:2121-2129.
  • 3Spertini O, Cordey AS, Monai N, et al. P-selectin glycoprotein lig-and-1 is a ligand for L-selectin on neutrophils, monocytes and CD34^+ hematopoietic progenitor cells. J Cell Biol, 1996; 135:523- 531.
  • 4Kishimoto TK, Jutila MA, Butcher EC. Identification of a human peripheral lymph node homing receptor: a rapidly downregulated adhesion molecule. Proc Natl Acad Sci USA, 1990: 87:2244- 2248.
  • 5Spertini O, Freedman AS, Belvin MP, et al. Regulation of leukocyte adhesion molecule-1 (TQ1, Leu-8) expression and shedding by normal and malignant cells. Leukemia, 1991; 5:300-308.
  • 6Bruserud O, Ulvestad E. Expression and rdease of adhesion molecules by human acute myelogenous leukemia blasts. Leukemia Res, 1999; 23:149- 157.
  • 7Butcher EC, Picker LJ. Lymphocyte homing and homeostasis. Science, 1996; 272:60- 66.
  • 8Spertini O, Luscinskas FW, Kansas GS, et al. Leukocyte adhesion molecule- 1 ( LAM- 1. L-selectin ) interacts with an inducible endothelial cell ligand to support leukocyte adhesion. J Immunol, 1991 ;147: 2565 - 2573.
  • 9Extermann M, Bacchi M, Moani N, et al. Relationship between cleaved L-selectin levels and the outcome of acute myeloid leukemia.Blood, 1998; 92:3115-3122.
  • 10Christopherson I, Piechoki M, Liu G, et al. Regulation of L-se-lectin expression by a dominant negative Ikaros protein. J Leukoc Biol, 2001 ; 69:675 - 683.

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湖南医科大学学报
2002年 第2期

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