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心衰与屏氧酶活性 被引量：2

Congestive heart failure and paraoxonase
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摘要 目的 :探讨慢性充血性心力衰竭时血清屏氧酶活性的变化。方法 :用苯醋酸作为底物测定心衰组和非心衰组患者血清屏氧酶活性。结果 :心衰组患者血清屏氧酶活性显著降低 ;经治疗 14天后心衰组患者血清屏氧酶活性明显上升 ;心衰时屏氧酶活性与肿瘤坏死因子 α呈负相关。结论 Objective To determine the changes of paraoxonase activity in patients with heart failure. Methods The serum paraoxonase (PON) activity of the heart failure group and controls was measured with phenylacetate as the substrate. Results The serum PON activity of the heart failure patients significantly decreased as compared with the controls; after the treatment, the PON activity of heart failure was largely elevated; and the PON activity of the patients with heart failure was negatively correlated with tumor necrosis factor α. Conclusion The PON activity of patients with congestive heart failure significantly decreases.
作者 谢小梅 赵水平
机构地区 中南大学湘雅二医院老年内科
出处 《湖南医科大学学报》 CSCD 北大核心 2002年第2期157-158,共2页 Bulletin of Hunan Medical University
关键词 充血性心力衰竭 屏氧酶活性 肿瘤坏死因子-Α PON heart failure,congestive paraoxonase activity tumor necrosis factor α
分类号 R541.6 [医药卫生—心血管疾病]
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参考文献9

  • 1Mackness MI, Mackness B, Durington PN, et al. Paraoxonase and coronary heart disease[J]. Curropin Lipidol, 1998,9:319-324.
  • 2Van Lenten BJ, Hama SY, de Beer FC, et al. Anti-inflammatory HDL becomes pro-inflammatory during the acute phase response[J]. J Clin Invest, 1995,996:2758-2767.
  • 3Kenneth R, Feingold RA, Menon AH, et al. Paraoxonase activity in the serum and hepatic mRNA levels decrease during the acute phase response[J] Atherosclerosis, 1998,139:307-315.
  • 4Hedrick CC, Hassan K, Hough GP, et al. Short-term feeding of atherogenic diet to mice results in reduction of HDL and PON that may be mediated by an immune mechamism [J] Arterioscler Thrombvasc Biol, 2000,20:1946-1952.
  • 5Kumon Y, Nakauehi Y, Kidawara K, et al. A longitudinal analysis of alteration in lecithin-cholesterol acyltransferase and paraoxonase activities following laparoscopic cholecystectomy relative to other parameters of HDL fuction and the acute phase response[J]. Scand J Immunol, 1998,48:419-424.
  • 6Levine B, Kalman J, Fillit HM, et al. Elevated circulating of tumor necrosis factor in severe chronic heart failre[J]. N Engl J Med, 1990,323:236-241.
  • 7Zhao SP, Zeng LH. Elevated plasma levels of tumor necrosis factor in chronic heart failure with cachexia[J]. Int J Cardiol, 1997,58:257-261.
  • 8Niebanetr J, Kemp M, Domingnez M, et al.Acute peripheral edema in patients with chronic heart failure is associated with endotoxemia and immune activation[J]. J AM Coll Cardiol, 1998,31:155A.
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同被引文献58

  • 1[1]Mackness MI, Mackness B, Durington PN, et al. Paraoxonase and coronary heart disease.Curr Opin Lipidol, 1998, 9:319-324.
  • 2[2]Rosenblat M, Hayek T, Hussein K, et al.Decreased macrophage paraoxonase 2 expression in patients with hypercholesterolemia is the result of their increased cellular cholesterol content: effect of atorvastatin therapy. Arterioscler Thromb Vasc Biol, 2004, 24:175-180.
  • 3[3]Reddy ST, Wadleigh DJ, Grijalva V, et al.Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids. Arterioscler Thromb Vasc Biol, 2001, 21:542-547.
  • 4[4]Deakin S, Leviev T, Guernier S, et al. Simvastatin modulates expression of the PON1gene and increases serum paraoxonase: a role for sterol regulatory element-binding protein-2. Arterioscler Thromb Vasc Biol,2003, 23:2083-2089.
  • 5[7]Boemi M, Sirolla C, Testa R, et al. Smoking is associated with reduced serum levels of the antioxidant enzyme, paraoxonase, in Type 2 diabetic patients. Diabet Med, 2004,21:423-427.
  • 6[8]Kopprasch S, Pietzsch J, Kuhlisch E, et al.Lack of association between serum paraoxonase 1 activities and increased oxidized low-density lipoprotein levels in impaired glucose tolerance and newly diagnosed diabetes mellitus. Clin Endocrinol Metab, 2003,88:1711-1716.
  • 7[9]Rozenberg O, Shih DM, Aviram M. Human serum paraoxonase 1 decreases macrophage cholesterol biosynthesis: possible role for its phospholipase-A2-like activity and lysophosphatidylcholine formation. Arterioscler Thromb Vasc Biol, 2003, 23:461-467.
  • 8[10]Aviram M, Hardak E, Vaya J, et al. Human serum paraoxonases (PON1) Q and R selectively decrease lipid peroxides in human coronary and carotid ayherosclerotic lesions:PON1 esterase and peroxidase-like activities. Circulation, 2000, 101:2510-2517.
  • 9[11]Jakubowski H, Ambrosius WT, Pratt H. Genetic determinants of homocysteine thiolactonase activity in humans:implications for atherosclerosis. FEBS Lett, 2001, 491:35-39.
  • 10[12]Frank R, Leus M, Wittekoek E, et al.Paraoxonase gene polymorphisms are associated with carotid arterial wall thickness in subjects with familial hypercholesterolemia.Atherosclerosis, 2000, 149:371-377.

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湖南医科大学学报
2002年 第2期

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