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乳腺癌相关基因的分子遗传学研究进展 被引量：5

Progress in molecular genetics of correlating genes of breast cancer
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摘要 对乳腺癌分子发病机理的研究已取得不少进展。其中涉及多种基因异常 ,包括易感基因、癌基因、抑癌基因等 ,对于乳腺癌的诊断、治疗及预后判断均具有提示作用。乳腺癌易感基因 ,尤其是 BRCA的异常在乳腺癌发病中更具意义。 Good progress has been made in the researches on correlating genes of breast cancer in recent years. Quite a few kinds of genes such as susceptibility gene, oncogene and tumor suppressor genes have been found with implications for diagnosis, therapy and prognosis. Abnormality of breast cancer susceptibility gene (BRCA) is of great significance, especially in the development of breast cancer.
作者 吴扬 杨莉 魏于全
机构地区 四川大学华西医院肿瘤生物治疗研究中心
出处 《中华医学遗传学杂志》 EI CAS CSCD 2002年第2期152-155,共4页 Chinese Journal of Medical Genetics
关键词 乳腺癌 相关基因 分子遗传学 易感基因 研究进展 Carcinogens Diagnosis Genes Tumors
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献32

  • 1Ralph S,David ML.In search of the tumour-suppressor functions of BRCA1 and BRCA2.Nature,2000,408∶429-432.
  • 2Miki Y,Swensen J, Shattuck Eidens D,et al.A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.Science,1994,26∶66.
  • 3David C,Yi W,Jun Q,et al.Requirement of ATM-dependent phosphorylation of BRCA1 in the DNA damage response to double-strand breaks.Science,1999, 286∶1162-1166.
  • 4Deng CX ,Brodie SG.Roles of BRCA1 and its interacting proteins.Bioessays,2000,22∶728-737.
  • 5Welcsh PL,Owens KN,King MC.Insight into the function of BRCA1 and BRCA2.Trends Genet,2000,16∶69-74.
  • 6Chen JJ,Sliver D,Cantor S,et al.BRCA1,BRCA2,and Rad51 operate in a common DNA damage pathway.Cancer Res,1999,59(7 Suppl)∶1752-1756.
  • 7Scully R.Genetic analysis of BRCA1 function in a defined tumour cell line.Mol Cell,1999,4∶1093-1099.
  • 8Cordeiro-Stone M,Makhov AM,Zaritskaya LS,et al.Analysis of DNA replication forks encountering a pyrimidine in the template to the leading strand.J Mol Biol,1999,289∶1207-1218.
  • 9Scully R,Puget N,Vlasakova K.DNA polymerase stalling,sister chromatid recombination and the BRCA genes.Oncogene 2000,19∶6176-6183.
  • 10Marmorstein LY,Ouchi T,Aaronson SA. The brca2 gene product functionally interacts with p53 and rad51. Proc Natl Acad Sci USA, 1998, 95∶13869-13874.

二级参考文献25

  • 1左文述,徐忠德,刘奇,等.现代肿瘤病理学 [M].济南:山东科学技术出版社,1995.1.
  • 2Barbacid M.Ras geae.Ann Rer Biochem,1987,S6;779.
  • 3Owens D,Spalding JW, Tennant RW, et al Genetic alterations cooperate with V-Ha -ras to accelerate multistage carcinogenesis in TG , AC transgenic mouse skin. Cancer Res,1995,55:371.
  • 4Theillet M,Rummel S,Ronacg E,et al. Expression of ras gene family mRNA in breast cancer, Eksponkol, 1993,15 : 301.
  • 5O'Reilly SM. The relationship between c-erbB-2 expression, Sphase fraction and prognosis in breast cancer. Br J Cancer, 1991,63:444.
  • 6Descotes F, Pavy JJ,Adessi GL. Human breast cancer correlation study between Her-2/neu amplification and prognostic factors in an unselected population. Anticancer Res,1993,13;119.
  • 7Lovekin C, et al. C-erbB-2 oncoprotein expression in primary and advanced breast cancer. Br J Cancer, 1991,63:439.
  • 8Parik S, et al. Pathological finding from the national survival adjuvant breast and bowel project:Prognostic significance of c-erbB-2 protein overexpression in primary breast cancer, J Clin Oncol,1990,8 : 103.
  • 9Callahan R, Campbel G. Mutation in human breast cancer : an overview, JNCI,1989,81;1780.
  • 10Donovan-Peluso M, Contento AM, Tobon H, et al Oncogene amplification in breast cancer. Am J Pathol, 1991,138;835.

共引文献11

同被引文献25

  • 1曹泽毅.中华妇产科学[M](第一版)[M].北京:人民卫生出版社,1999.605-620.
  • 2史良中.乳腺病理学[M].第一版.上海:上海医科大学出版社,1999.95-107.
  • 3Chomczynski P.and Sacchi N.Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction[J]. Analytical Biochemistry, 1987,162:156-159.
  • 4Schena M.DNA microarrays A practical approach[M]. 1sted.Londen:Oxford university press,1999.93-94.
  • 5Derisi J,Penland L,Brown PO,et al.Use of a cDNA microarray to analyse gene expression patterns in human cancer[J]. Nat. Genet,1996,14(4):457-460.
  • 6Golub T.R,Slonim D.K,Tamayo P.et al.Molecular Classification of Cancer:Class Discovery and Class Prediction by Gene Expression Monitoring[J].Science, 1999,286(5439):531-537.
  • 7Zhang H.P,Yu C.Y,Singer B and Xiong M.et al.Recursive partiting for tumor classification with gene expression microarray data[J]. Proc.Natl.Acad.Sci.USA,2001, 98(12):6730-6735.
  • 8Takahashi M,Rhodes D.R,Furge K.A.et al.Gene expression profiling of clear cell renal cell carcinoma:Gene identification and prognostic classification[J].Proc.Natl.Acad.Sci.USA,2001,98(17):9754-9759.
  • 9Adams SM, Sharp MG, Walker RA.et al.Differential expression of translation-associated genes in benign and malignant human breast tumours[J]. Br J Cancer,1992,65(1):65-71.
  • 10Kikuno R, Nagase T, Ishikawa K. et al. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro[J]. DNA Res 1999,6(3):197-205.

引证文献5

二级引证文献7

中华医学遗传学杂志
2002年 第2期

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