摘要
目的:探讨原发性高血压病的发病机制。方法:对28例原发性高血压患者和16名正常人测定了血清胰岛素样生长因子1(IGF1),并与高血压分级进行了相关分析。结果:原发性高血压患者IGF1水平显著低于正常人(分别为26.22μg/L±20.23μg/L和48.02μg/L±33.43μ/L,P<0.05),且IGF1水平与临床分级呈负相关(=-0.437,P<0.05)。 结论:IGF1可能参与了原发性高血压的病理生理过程。
Objective: IGF1 in hypertensives was determined to investigate the possible mechanism of hypertension. Methods: The levels of serum IGF1 in 28 patients with essential hypertension and 16 normal individuals were determined and correlation analysis was done between them and clinical grading of hypertension. Results: IGF1 level in patients with essential hypertension (26.22μg/L±20.23μg/L) was significantly lower (P<0.05) than that in normal controls (48.02μg/L±33. 43/μg/L) and IGF1 level correlated negatively with clinical grading (r = -0.437, P<0.05). Conclusions; IGF1 is probably involved in the patho-physiological process of essential hypertension.
