兔脑外伤后脑灌注压高低与脑水肿的实验研究

Experimental study on the cerebral perfusion pressure and brain edema following brain injury in rabbit

目的 了解不同灌注压对脑水肿的影响。方法 采用低温冷冻动物模型 ,将 30只动物随机分为三组 ,每组 10只 ,即高灌注压、适当的低灌注压、对照组。通过观察Evans蓝扩散距离、脑组织含水量的不同两项指标来观察脑水肿程度。结果 高灌注压组致伤灶Evans蓝扩散距离最大(1 85± 0 11cm) ,脑组织含水量也最高 (79 80 %± 0 71% ) ,适当低灌注压组上述两项指标最低 (1 71± 0 10cm ,76 99%± 0 6 2 % )对照组数值居中 (1 80± 0 12cm ,78 89%± 0 87% )。三者相互比较有显著性意义 (P<0 0 5 )。结论 灌注压越高越容易加重脑水肿。适当的灌注压降低 ,有助于改善脑水肿。

Objective To understand the relation of CPP and brain edema.Methods Adopt cold injury edema animal model, Three animal groups were assigned as high CPP group (13 33 17 33kPa), proper low CPP group (8 10 67kPa) and control CPP groups(10 14 67kPa). Change of brain edema was analyzed by Evans blue extravasation and brain water content. Results The change of high CPP groups in Evans blue extravasation and brain water content was the highest among three groups (1 85±0 11cm,79 80%±0 71%), while that of the low CPP groups was the lowest (1 71±0 10cm,76 99%±0 62).Conclusions Our study showed that the higher CPP the worsened vasogenic brain edema. In low CPP groups, worsen brain edema is not found in spite of decreasing cerebral blood flows.