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几种自身抗体检测对类风湿性关节炎的意义 被引量:15

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摘要 类风湿性关节炎是一种常见的自身免疫性疾病 ,其早期诊断困难 ,而早期又是疾病发展最快的阶段 ,易造成骨质破坏 ,从而晚期严重致残 ,故早期诊断和治疗甚为重要。自身抗体的检测为其早期诊断提供了重要的依据 ,并为探索其发病机制提出了新的见解 ;其中有意义的自身抗体有 :抗角蛋白丝聚集素 (原 )抗体、抗Sa抗体、RA33/ 36。
作者 高丽霞
出处 《国外医学(临床生物化学与检验学分册)》 2002年第2期79-80,共2页 Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine
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  • 1Schroder AE, Greinner A, Seyfert C, et al. Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis[J]. Proc Natl Acad Sci USA, 1996,93: 221-225.
  • 2Masson-Bessiere C, Sebbag M, Durieux JJ et al. In the rheumatoid pannus, anti-filaggrin autoantibodies are produced by local plasma cells and constitute a higher proportion of IgG than in synovial fluid and serum[J]. Clin Exp Immunol, 2000,119 : 544-552.
  • 3Schellekens GA, De-Jong BAW, Van-Den-Hoogen FHJ,et al. Citrulline is an essential constitutent of antigenic determinants recognized by rheumatoid arhtritis specific autoantibodies[J]. J Clin Invest, 1998,101 : 273-281.
  • 4Girbal-Neuhauser E, Durieux JJ, Arnaud M et al. The epitopes targeted by the rheumatoid arthritis associated antifilaggrin autoantibodies are posttranslationally generated on various sites of(pro) filaggrin by deimination of arginine residues[J]. J Immunol, 1999,162: 585-594.
  • 5Carelle C, Reparon S, Wim JVE, et al. Secretion of anticitrulline containing peptide antibody by B lymphocytes in rheumaotid arhtritis [J]. Arthritis Rheu, 2001,44 ( 1 ) : 41-47.
  • 6Simon M, Girbal E, Sebba M et al. The cytokeratin Filament-aggregating protein filaggrin is the target of the socalled′ antikeratin antibodies′ autoantibodies specific for rheumatoid arthritis[J]. J Clin Invest 1993,92:1387-1393.
  • 7Hoet RM, Voorsmit RACA, Van-Venrooij WJ. The perinuclear factor, a rheumatoid arthritis specific autoantigen is not present in keratohyalin granules of cultured buccal mucosa cells[J]. Clin Exp Immunol, 1991,84: 59-65.
  • 8Menard HA, Lapointe E, Rahdi MD, et al. Insights into rheumatoid arthritis derived from the Sa immune system [J]. Arthritis Res, 2000,2(6) :429-432.
  • 9Hayem G, Chazerain P, Combe B, et al. Anti-Sa antibody is an accurate diagnostic and prognostic marker in adult arthritis[J]. J Rheumatol, 1999,26(9): 2069.
  • 10Steiner G, Slriner K, Hassfeld W, et al. Clinical and immunological aspects of autoantibodies to RA33/hn RNP-A/B protein a link between RA, SLE and MCTD[J]. Mol Biol Rep 1996,23(3-4) :167-171.

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