尼莫地平对正常和椎基底动脉供血障碍时耳蜗血流的影响

Effects of nimodipine on cochlear blood flow with normal and vertebrobasilar insufficiency status

目的 :探讨尼莫地平对耳蜗血流的影响。方法 :用激光多普勒血流计对 2 2只正常及椎基底动脉供血障碍时豚鼠耳蜗血流测量。结果 :低浓度、临床常用浓度、高浓度的尼莫地平对内耳正常供血状态下或是椎基底动脉供血不足内耳缺血状态下的耳蜗血流均无增加作用。结论 :尼莫地平不能增加耳蜗血流反而降低耳蜗血流 ,在治疗内耳微循环障碍性疾患时应慎用。

Objective:To study effect of nimodipine (ND) on cochlear blood flow(CBF).Method:CBF was measured in twenty-two guinea pigs by laser Doppler flowmetry(LDF).Result:Nimodipine decreased CBF following the decrease of systemic BP and present a dose dependent mode, neither the dose of nimodipine is lower, normal and higher, nor the animal is under the status of normal supply of inner ear blood flow and ischemia of inner ear caused by vertebrobasilar insufficiency(VBI).Conclusion:It suggested that this compound may be of little clinical use to elevate CBF.