羟丙基三甲基氯化铵壳聚糖的制备及其吸湿、保湿性能

Preparation, Moisture Adsorbability and Retentivity of 2-Hydroxypropyltrimethyl Ammonium Chloride Chitosan

用 2 ,3 -环氧丙基三甲基氯化铵对壳聚糖进行改性 ,制备水溶性的壳聚糖季铵类衍生物羟丙基三甲基氯化铵壳聚糖 (HACC) ,应用胶体滴定法测定产物的季铵盐总取代量为 3 .3 9mmol/ g,其中 N上取代量和取代度分别为 3 .0 7mmol/ g、5 8.1 % .IR谱图分析证实以 N上取代为主 .研究产物的吸湿、保湿性能 ,结果表明其吸湿性与透明质酸 (HA)相当 ,保湿性能优于 HA.初步的抑菌性能测试结果表明 ,对金黄色葡萄球菌ATCC2 5 92 3的最低抑菌浓度 (MIC)为 62 5 mg/

Hydroxypropyltrimethyl ammonium chloride chitosan(HACC), a water solube quaternary ammonium salt of chitosan, was prepared by the reaction of chitosan with 2,3 epoxypropyltrimethyl ammonium chloride. The content of quaternary cations(R 4N +) determined by the method of colloid titration with polyanion(PVSK) was 3 39 mmol/g, the content and degree of substitution of R 4N + in N atom were 3 07 mmol/g and 58 1% respectively. IR spectra revealed that the most substituents were attached on N atom of chitosan. The moisture adsorbability of HACC was as good as that of hyaluronic acid(HA), the moisture retentivity of HACC was better than that of HA, the minimum inhibitory concentration(MIC) of HACC for staptytococous aureus (ATCC25293) was 625 mg/L.