晶珠肝泰舒联合拉米夫定治疗慢性乙型肝炎临床疗效观察

Study on Combination Therapy of Jing Zhu Gan Tai Shu Capsule and Lamivudine in Treating Hepatitis B

目的:观察晶珠肝泰舒联合拉米夫定治疗慢性乙型病毒性肝炎(慢乙肝)的效果。方法:将60例慢乙肝患者随机分成晶珠肝泰舒联合拉米夫定组(治疗组)、拉米夫定组(对照组)各30例,疗程均为3个月,观察临床症状、生化指标、病毒复制指标,以及特异性细胞免疫指标IFN-γ、IL-4水平的变化。结果:治疗3个月后,两组在HBsAg、HBeAg、HBV DNA阴转,肝功能复常,以及症状、体征的恢复等方面差别无统计学意义(P>0.05),但IFN-γ、IL-4水平变化则有显著性差异。结论:在较短期的疗程中,晶珠肝泰舒联合拉米夫定治疗慢乙肝,对调整特异性细胞免疫指标IFN-γ、IL-4有较好作用。

Objective:To observe the effect of the combination therapy of traditional herbal medicine and Lamivudine in treatment of hepatitis B. Method: There were 60 patients to be divided equality into two groups at random, one for combination therapy and the another for control (only Lamivudine). The therapy course was lasted 3 months. During the course the serum transaminase, bilirubin, albumin, HBV marker, HBV DNA (quantu-PCR) were detected before and after. The data were analysised by statistics. Results i There were no significant differences in the negative rate of HBsAg,HBeAg,HBV DNA,the value of serum transaminase,bilirubin,albumin level,and the improvement of symptoms and physical sign(PX). 05). Ability as INF-7 and IL-4 displayed a obvious difference. Conclusion: After the combination therapy the levels of IFN-Y and IL-4 were improved it could be related with the clearance of HBV in continuance therapeutic.