(1R,3R)-1-氨基-1,3-二羧基环丁烷衍生物桥联环糊精与一组低分子量多肽之间的包合行为

Inclusion Behavior of the Double Cyclodextrin Bridged with (1R,3R)-1-Amino-Cyclobutane-cis-1,3-Dicarboxylic Acid Derivative to the Peptides with Low Molecular Weight

The interactions between several peptides with low molecular weight (guest, NH2 Arg Arg Trp Trp H 2; NH2 Arg Trp Arg Trp H 3; NH2 Trp Arg Arg Trp H 4; NH2 Arg Arg Trp Trp Trp Trp H 5; NH2 Trp Trp Arg Arg Trp Trp H 6; NH2 Arg Arg Trp Trp Trp Trp Trp Trp H 7; NH2 Arg Arg Trp Trp Trp Trp Trp Trp Trp Trp H 8) and β cyclodextrin dimer (host, 1) bridged with the derivative of (1R, 3R) 1 aminocyclobutane cis 1,3 dicar boxylic acid were investigated by using fluorescence polarization method in buffer aqueous solution (pH 7.4) at 298K. The binding constants of the cyclodextrin dimer 1 to the guests 2 8 were determined. It was shown that there was a cooperative action of the two cavities of a cyclodextrin dimer in the binding of large substrates, and that the structure and properties of amino acid in the peptides played very important roles in the synergic complexation between host and guest.