尖锐湿疣损害中转化生长因子α、β_1的表达

Expression of Transforming Growth Factor α,β_1(TGF-α、β_1) in Lesions of Condyloma Acuminatum

目的 探讨TGF α、β1在尖锐湿疣 (CA)发病机制中的作用。方法 采用免疫组化SP法检测 30例CA损害中TGF α、β1的原位表达 ,并以 2 0例健康男性正常包皮组织作为对照。结果 两组TGF α、β1表达阳性率均相同 ;CA组TGF α、β1表达阳性者中的表达程度分别显著高于对照组 (P <0 .0 0 1) ;其过度表达率也分别明显高于对照组 (P <0 .0 0 5 )。结论 CA组织细胞可合成及分泌较多的TGF α、β1,作为中间介质在CA发病中发挥致细胞增生的作用。

Objective To investigate the effects of TGF-α?β 1 in pathogenesis of condyloma acuminatum(CA).Methods The TGF-α?β 1 expression in situ in the lesions of 30 CA patients and the normal prepuce tissue of 20 healthy men was examined by immunohistochemistry assay.Results Although there was a same positive incidence in the two groups for TGF-α?β 1 expression,the expressive intensity and the overexpressive incidence of TGF-α?β 1 in the CA group were significantly higher than those in the controls(P<0.001 and 0.005 respectively).Conclusion The cells in CA lesions may synthesize and secrete more TGF-α?β 1 and result in its proliferative effects as a medium in the mechanism.