共刺激分子在系统性红斑狼疮患者外周血淋巴细胞中的表达

Expression of Costimulatory Molecules in Peripheral Blood Lymphocytes of Patients with Systemic Lupus Erythematosus

目的 研究CD80、CD86及CD2 8共刺激分子在SLE发病中的作用。方法 采用流式细胞仪检测 40例不同病程系统性红斑狼疮 (SLE)患者外周血淋巴细胞上CD80、CD86及CD2 8的表达水平。结果 SLE活动组及静止组淋巴细胞上CD80及CD86的表达水平均明显高于正常对照组 ,活动组又显著高于静止组 ,且与SLEDAI呈正相关 ;而CD2 8的表达水平与正常对照组差异无显著性 ,且与SLEDAI亦无相关关系。结论 SLE的发生与发展与B7/CD2 8共刺激途径异常有关。

Objective To investigate the role of costimulatory molecules CD80,CD86 and CD28 in the occurrence and development of systemic lupus erythematosus(SLE).Methods CD80,CD86 and CD28 were detected in circulating lymphocytes in peripheral blood of 40 patients with SLE using flow cytometry and monoclonal antibodies technology.Results Patients with SLE had a high percentage of lymphocytes expressing CD80 and CD86 in their peripheral blood.The expression of CD80 and CD86 in active group of SLE was higher than that of inactive group.A positive correlation between SLE DAI and the expression of CD80 and CD86 was found.But the percentage of lymphocytes expressing CD28 had not difference from the control group.Conclusion Costimulatory molecules B7/CD28 in peripheral blood lymphocytes might play a role in the pathogenesis of SLE.