自身免疫性甲状腺疾病与慢性荨麻疹关系探讨

Chronic Urticaria and Autoimmune Thyroid Diseases

目的 探讨慢性荨麻疹与自身免疫性甲状腺疾病之间的关系。方法 采用放射免疫法对 5 8例慢性荨麻疹患者及 30例正常体检人群的甲状腺功能及抗甲状腺自身抗体进行了检测。结果 5 8例慢性荨麻疹患者中 ,有 8例( 13.8%)血清中存在抗甲状腺球蛋白抗体 (TGA) ;7例 ( 12 .1%)存在抗甲状腺微粒体抗体 (TMA) ;慢性荨麻疹组的TGA和TMA水平均显著高于对照组 (t值分别为 2 .76 2和 2 .6 95 ,P <0 .0 1)。但两组的T4 、RT3 、FT3 、TSH值比较差异均无显著性 (P >0 .0 5 )。结论 慢性荨麻疹的发病有自身免疫机制参与。

Objective To study the relationship between chronic urticaria and autoimmune thyroid diseases.Methods Thyroid function tests and thyroid autoantibodies were measured by radioimmuneassay in 58 patients with chronic urticaria and 30 healthy volunteers.Results Eight of 58 cases of patients with chronic urticaria(13.8%) were found to have thyroglobulin antibodies(TGA) and seven patients(12.1%) thyroid microsomal antibodies(TMA) respectively.The serum level of TMA and TGA in chronic urticaria was significantly higher than that in control cases(t=2.762,2.965,P<0.01).But the levels of T 4,RT 3,FT 3 and TSH in patients with chronic urticaria were not significant statistically differente compared to those of the normal control cases(P>0.05).Conclusion Autoimmunity may play a role in the pathogenesis of chronic urticaric