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CA_(125)在卵巢癌监测中的应用 被引量:2

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摘要 目的 :探讨动态监测CA1 2 5在卵巢癌随访中的应用价值。方法 :采用放射免疫法测定卵巢癌患者术前、术后及化疗前、后血清CA1 2 5变化。结果 :卵巢癌术后残留灶≥ 2cm组CA1 2 5值显著高于残留灶 <2cm组 ,残留灶 <2cm组显著高于完全切除组 (P均 <0 .0 1 ) ;术后第一次化疗前后CA1 2 5值下降程度与患者生存时间相关 ,生存时间 >2 4个月化疗前后CA1 2 5值下降差异有显著性意义 (P <0 .0 5) ,生存时间≤ 2 4个月化疗前后CA1 2 5值下降差异无显著性意义 (P >0 .0 5) ;肿瘤病理分级高分化者CA1 2 5值显著低于低分化者 (P <0 .0 1 ) ,但生存时间两者差异无显著性意义 (P >0 .0 5)。临床分期Ⅰ期卵巢癌CA1 2 5值显著低于Ⅱ、Ⅲ、Ⅳ期 (P <0 .0 1 ) ,但Ⅱ、Ⅲ、Ⅳ期之间相比差异无显著性意义 (P >0 .0 5) ,且CA1 2 5值与临床分期不成正相关。结论 :CA1 2 5可作为卵巢癌术后化疗疗效、病情监测、预后估价及预测复发的敏感指标 。
出处 《温州医学院学报》 CAS 2002年第2期105-106,共2页 Journal of Wenzhou Medical College
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