抑郁症状与睡眠脑电图参数的相关分析

Analysis correlations between depressive symptoms and sleep electroencephalographic(EEG) parameters in 18 patients with depression

目的调查抑郁症状与睡眠脑电图参数的相关性。方法对停用精神药物3d的18例病人估价其汉密顿抑郁量表(HAMD)总分/诸因子分与14项睡眠脑电图参数的相关性。结果(1)焦虑/躯体化因子与快波睡眠百分率呈显著负相关性(r=-0.5097,df=16,P<0.05);(2)绝望感因子与慢波睡眠2相百分率呈显著正相关性(r=0.4874,df=16,P<0.05);(3)绝望感因子与快波睡眠活动量及强度分别呈显著负相关性(r分别为-0.5067和-0.5657,df=16,P均<0.05)。结论慢波睡眠2相百分率、快波睡眠活动量及强度可作为绝望感因子的生物学标记。

Objective To explore correlations between depressive symptoms and sleep EEG parameters. Method It was estimated correlations between HAMD total score/various factor scores and 14 parameters of sleep EEG in 18 patients with depression no taking psychotropics for 3 days.Result (1)There was a negative correlation between anxiety/somatization factor's score and rapid eye move(REM) sleep percent(r=-0.5097,df=16,P< 0.05); (2)There was a positive correlation between hopeless factor's score and non REM sleep 2 phase percent(r=0.4874,df=16, P< 0.05);(3)There was a negative correlation between hopeless factor's score and REM sleep activity/intensity( r=-0.5067 and -0.5657,respectively,df=16,P< 0.05). Conclusion It could be biological markers of hopeless for non REM sleep percent and REM sleep activity/intensity.