纳络酮治疗新生儿缺氧缺血性脑病的疗效分析

Analysis of the effect of naloxone on neonatal hypoxia-ischemic encephalopathy

目的 观察纳络酮对新生儿缺氧缺血性脑病的临床疗效。方法 对 32例缺氧缺血性脑病的患儿使用纳络酮治疗 ,均给予静脉用药 ,第 1天 0 4mg加入 1 0 %葡萄糖 30ml中静滴 ,第 2、3天给 0 8mg加入1 0 %葡萄糖 50ml中静滴 ,每次在 4h左右滴完 ,连续 3d。结果 32例缺氧缺血性脑病中 ,重度 1 7例 ,存活1 1例 ,死亡 6例 ,留后遗症 4例 ;中度 8例 ,存活 7例 ,死亡 1例 ,留后遗症 1例 ;轻度 7例 ,均存活 ,无后遗症发生。结论 新生儿缺氧缺血性脑病使用纳络酮能提高成活率 。

Objective To observe the effect of naloxone on HIE.Methods Thirty two cases of HIE received naloxone dissolved in 30ml 10%GS for 3 days intravenously.The dosage of naloxone was 0.4mg in the first day,and 0.8mg in the second and third day,respectively.The time of administration was about 4 hours.Results Of 17 cases of severe HIE,11 cases survived but 4 cases with sequelae,and 6 cases died.Of 8 cases of moderate HIE,7 cases survived but 1 case with sequelae,and 1 case died.All 7 mild cases survived without sequelae.Conclusion Naloxone can increase the survival rate of HIE and decrease the sequelae.