紫杉醇与铂类联合治疗晚期卵巢上皮癌疗效分析

Paclitaxel and platinum combining treat for terminal ovarian epithelioma

目的 观察紫杉醇与铂类联合化疗治疗晚期卵巢上皮癌的疗效及毒性反应。方法 紫杉醇 135mg·m-2 ,静滴 ,滴完 30min后再静脉或腹腔滴注顺铂 6 0～ 70mg·m-2 或卡铂 2 5 0mg·m-2 ,2 8d为一疗程间隔 ,所有患者均接受两个疗程以上化疗。结果 2 0例晚期卵巢癌中 (其中初治 4例 ,复治 16例 )完全缓解 2例 ,部分缓解 6例 ,稳定 8例 ,进展 4例。总有效率 4 0 %。常见毒性有骨髓抑制、恶心呕吐、肌痛和关节痛、脱发等。大部分患者为Ⅰ～Ⅱ度反应 ,患者耐受良好。结论 紫杉醇与铂类联合治疗晚期卵巢癌 ,疗效较好 ,且毒副作用可以耐受。

AIM The therapeutic and toxic effect of Pacliaxel and Platinum combining treat for terminal ovarian epithelioma wese studied. METHODS Paclitaxel iv. 135 mg/m 2 30 minutes after completing iv. Paclitaxel, cisplatin(60～70 mg/m 2) or carboptatin(250 mg/m 2) were given iv or ip. 28 days for one period of treatment. All patients receive at least two periods of treatment. RESULT In the 20 terminal ovarian epithelioma patients (4 for initial treatment, 16 for again treatment), 2 were completely recovered, 6were partly recovered, 8 were stable, and 4 were developing. The total rate of recovery was 40%. The frequent toxic reactions were marrow inhibition, nausea and vomit, muscle pain, arthrosis pain, loss of hair, etc. The toxic reactions of mostly patients were Ⅰ～Ⅱ level. The tolerance of patients was good. CONCLUSION The therapeutic effect of Paclitaxel and Platinum combining treat for terminal ovarian epithelioma is good and the toxic effects are tolerable.