期刊文献+

小鼠前庭感觉器官发育的形态学研究 被引量:1

Morphological study on the development of mouse vestibular sensory organ
下载PDF
导出
摘要 目的 :探讨小鼠前庭感觉器官发育的特点及规律。方法 :应用光镜对昆明种小白鼠的前庭感觉器官从胚胎第 10天 (ED10 )至出生后第 14天 (P14)的发育过程进行形态学研究。结果 :小鼠前庭感觉器官的形态发育过程可分为四个时期 :1)耳泡发育期 ;2 )前庭感觉器官上皮增殖期 ;3)前庭感觉器官上皮分化期 ;4)前庭感觉器官发育成熟期。结论 :小鼠在出生时 ,前庭感觉器官的上皮已充分分化发育 ,出生后 Objectives:To explore the characteristic and rules of vestibular sensory organ development in mice.Methods:The developing vestibular sensory organ of Kunming white mice aged from the tenth embryonic day(ED10) to fourteenth postnatal day(P14) were studied by light microscopy.Results:The development process of vestibular sensory organ may be divided into 4 periods according to the morphology changes.they are:(1)The development stage of otocyst;(2)The proliferative stage of the vestibular sensory organ;(3)The stage of defferentiation of vestibular sensory;(4)The maturation of vestibular sensory structures.Conclusion:The contiation of vestibular sensory epithelia had well finished by P1. The structures of vestibular sensory organ had achieve full development at 2th week after birth.
出处 《中国民政医学杂志》 2002年第1期15-17,共3页 Medical Journal of Chinese Civil Administration
基金 河南省科委科技攻关项目 ( 981170 5 0 9)
关键词 实验动物学 小鼠 前庭 感觉器官 发育 形态学 感觉上皮 Vestibule Sensory epithelia Development Mouse
  • 相关文献

参考文献9

  • 1Zhou XN, Van De water TR. HEMA hydrogels as a subtratum for culture of inner ear and statoacoustic ganglin explants. Rearing Res,1987.927 : 183 ~ 187
  • 2Repros J, Van de Water TR, Bernd P.Tempoal pattern of nerver growth factor receptor expression in developing cochlear and vestibular ganglia in queal and mouse. Anat Embryol 1991,184:421 - 432
  • 3Schectersom LC.Bothwell M.Neurotrophin and neurotrophin receptor mRNA expression in developing inner ear.Hearing Res.1994.73:92-100.
  • 4Pirvola U.Ylikoski J,Palgij.et al.Brain -derived neurotrophic factor and neurotrophic factor and neutrophin-3 mRNA in the peripheral target fields of developing inner ganglia.Proc Natl Acad USA.1992.89:9915-9919.
  • 5Kikuchi T, Tonosaki A, Takasaka T.Development of apical surface structures of mouse otic placode. Acta otolaryngol stockh, 1998,106 :200-207
  • 6Spoendlin H.Neural anatomy of the inner ear. In: abn AF, Santos.Sacchi J eds. Physiology, of the ear. New York:Raven Press, 1988,201-236
  • 7Coleman JR.Development of audiury system structure.In Coleman JR.eds.Development of sensory system in mammals.New York:Raven Press 1990, 205 - 247
  • 8Ruben RJ.Development of the inner ear of the mouse:A radicautographic tody of teminal mitosis.Acta Otolaryngol Suppl 1967,20:1 -44
  • 9Lim DJ.Anniko M.Developmental morphology of the mouse inner ear.Acta Otolaryngol,1985,42 : 1- 69

同被引文献16

  • 1张继帅,谭晓红,王友亮,程萱,高翔,杨晓.Cre重组酶在软骨组织特异性转基因小鼠中表达的时空分布[J].军事医学科学院院刊,2004,28(6):509-512. 被引量:2
  • 2卢云云,杨仕明,郭维维,胡吟燕,杨伟炎,杨晓.Smad4基因敲除对小鼠听力和前庭功能的影响[J].听力学及言语疾病杂志,2005,13(6):424-426. 被引量:9
  • 3刘少锋,周梁,李华伟,沈云珍.小鼠前庭器官的形态发生[J].听力学及言语疾病杂志,2005,13(6):427-429. 被引量:3
  • 4侯昭晖,杨仕明,郭维,胡吟燕,孙建和,于宁,张继帅,杨晓,韩东一,杨伟炎.Smad4条件基因敲除小鼠听功能初步研究[J].中华耳科学杂志,2006,4(3):176-180. 被引量:7
  • 5Chatterjee S, Kraus P, Lufkin T. A symphony of inner ear developmental control genes. BMC Genet, 2010, 11 : 68.
  • 6Brown ST, Martin K, Groves AK. Molecular basis of inner ear induction. Curr Top Dev Biol, 2003, 57: 115-149.
  • 7Yang SM, Deng AC, Huang DL, et al. The role of Smad4 in vestibular development in mice. Int J Dev Neumsci, 2011, 29: 15-23.
  • 8Yang X, Li C, Herrera PL, et al. Generation of Smad4/Dpc4 conditional knockout mice. Genesis, 2002, 32: 80-81.
  • 9Ohta S, Mansour SL, Schoenwolf GC. BMP/SMAD signaling regulates the cell behaviors that drive the initial dorsal-specific regional morphogenesis of the otocyst. Dev Biol, 2010, 347 : 369- 381.
  • 10Chang W, Lin Z, Kulessa H, et at. Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements. PLoS Genet, 2008, 4 : el000050.

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部