扩张皮肤微循环变化特征及其对血供的影响

Microcirculation pattern of expanded skin and its influence on skin blood supply

目的 研究扩张皮肤微循环变化特征 ,确定其稳定血供形成时间。方法 用微循环显微成像、碱性磷酸酶组织化学染色等形态学研究手段 ,对扩张皮肤微血管直径、密度、血流速度、流量等指标进行观测。结果 扩张组各观测指标均明显高于对照组 (P <0 .0 1)。微血管直径、血流量从第 1～ 3周逐渐增加 ,此后呈下降趋势 ;微血管密度在第 1～ 4周逐渐增加 ,第 5周出现下降 ;血流速度则在较高水平维持。结论 皮肤扩张后微循环功能增强 ,早期以血管增生扩张为主 ,以后逐渐稳定并向正常组织微循环状态转化 ,其稳定血供的形成至少需要

Objective To study the microcirculation pattern of expanded skin and its influence on skin blood supply. Methods The microvessel diameter, blood velocity and blood volume were recorded under the microcirculatory imaging system and the microvessel density was measured by enzyme histochemical staining and medical imagine analysis. Results Compared with the control group, all the recorded values rose obviously in every expanded groups ( P <0.01). The microvessel diameter and blood volume increased from the first week to the third week and then declined. The microvessel density was increased from the first week to the fourth week and then also declined later. The blood velocity kept in a high level from the first expanding period on.Conclusions The microcirculation function is enhanced by expansion.Its new stable microvessel system develops from angiogenesis and microvessel expansion at the early period. Only after one month expansion can expanded skin gain its stable blood supply.