天丹强肝胶囊对急慢性肝损伤的作用

Pharmacological Effects of Tiandanqianggan Capsules on Acute or Chronic Hepatic Injury

[目的 ]观察天丹强肝胶囊对急慢性肝损伤的作用。 [方法 ]用 D-氨基半乳糖和 CCl4 致小鼠和大鼠急慢性肝损伤 ,比较天丹强肝胶囊与护肝胶囊、联苯双脂滴丸对急慢性肝损伤动物血清谷丙转氨酶 (GOT)、谷草转氨酶(GCT)、总蛋白 (TP)、白蛋白 (AL B)、白蛋白 /球蛋白比值 (A/ G)及其肝纤维增生程度的影响。 [结果 ]与生理盐水组比较 ,天丹强肝胶囊两个剂量组均可明显降低慢性肝损伤大鼠血清 GPT、GOT(P<0 .0 5 ) ,明显降低其肝纤维增生程度 (P<0 .0 5 ) ,高剂量组能升高其血清 TP、AL B值及 A/ G比值 ;与护肝胶囊比较 ,天丹强肝胶囊的上述保肝作用指标无明显的统计学差异 ;与联苯双脂比较 ,该药降低慢性肝损伤大鼠的血清 GPT、GOT的作用较弱 ,升高其血清 TP、AL B和 A / G比值及降低其肝纤维增生程度无明显的统计学差异 ,而该药降低急性肝损伤小鼠血清 GPT作用优于联苯双酯。 [结论

The purpose is to observe the effects of Tiandanqianggan capsules on acute or chronic hepatic injury. The mouse and rat models of acute and chronic hepatic injury were made by D aminogalactose and CCl\-4. The effects of Tiandanqianggan capsules on serum GPT, GOT, TP, ALB, A/G rate and hepatic fiber proliferation in acute or chronic hepatic injury mice or rats were compared with those of Baogan capsules and Bifendate drop pill. The serum GPT, GOT and hepatic fiber proliferation in chronic hepatic injury model were significantly decreased in two dosage groups of Tiandanqiangan capsules (\%P\%<0.05) and the serum TP, ALB and A/G rate in chronic hepatic injury model were increased in higher dosage group of Tiangdanqiangan capsules, compared with normal saline; the decreases of serum GPT, GOT in chronic hepatic injury model in the drug group were a little less than those in Bifendate group and the increase of serum TP, ALB and A/G rate and the decrease of hepatic fiber proliferation in chronic hepatic injury model in the drug group had no significantly statistical difference with those in Bifendate group; the decrease of serum GPT in acute hepatic injury model in the drug group was more than that in Bifendate group; compared with Hugan capsules, the above liver protective effects of the drug had no significantly statistical difference. [CONCLUSION]Tiandanqianggan capsules have a marked liver protective effect on acute or chronic hepatic injury.