吸入糖皮质激素对COPD患者肺功能和气道炎症的影响

Effects of Inhaled Glucocorticoids on Pulmonary Function and Airway Inflammation in Patients with Chronic Obstructive Pulmonary Disease

目的观察慢性阻塞性肺疾病(COPD)患者吸入糖皮质激素后,肺功能和气道炎症的变化,从而探讨吸入糖皮质激素在COPD治疗中的作用.方法测定COPD患者规则吸入必可酮气雾剂(600 μg/d)6周前后,1秒用力呼气容积/一秒用力呼气容积的预计值(FEV1/pre-FEV1%)、诱导痰中细胞总数和白细胞分类计数的变化.结果COPD患者治疗后FEV1/pre-FEV1%较治疗前明显提高,差异有显著性;而诱导痰中细胞总数和白细胞分类计数的差异无显著性.结论吸入糖皮质激素能改善COPD患者的通气功能,而对其气道炎症无影响.

Objective To observe changes of pulmonary function and airway inflammation in patients with chronic obstructive pulmonary disease (COPD) after inhalation of glucocorticoids and to explore the effects of inhaled glucocorticoids in treatment of COPD. MethodsThe changes of forced expiration volume per second (FEV 1) /predicted FEV 1(pre-FEV 1) ratio(FEV 1/pre-FEV 1%), total cell counts and differential leucocyte counts in induced sputum of patients with COPD were observed before and after regular inhalation of beclomethasone dipropionate (600g/d) for 6 weeks. ResultsThe FEV 1/pre-FEV 1% in patients with COPD after treatment was obviously improved as compared with that before treatment (P<0.05). However, no significant changes of total cell counts and differential leucocyte counts in induced sputum were shown after treatment. ConclusionInhaled glucocorticoids can efficiently improve the ventilatory function of patients with COPD, but can not affect their airway inflammation.