西地那非治疗骨盆骨折尿道损伤后并发勃起功能障碍

Sildenafil in treatment of erectile dysfunction caused by pelvis trauma and prostato membranous urethral injury

目的 :观察西地那非治疗骨盆骨折尿道损伤后阴茎勃起功能障碍 (ED)的疗效和安全性。方法 :采用随机、交叉、双盲和安慰剂对照方法 ,将 5 2例骨盆骨折尿道损伤后ED病人 ,分为A ,B 2组 ,A组 2 8例 ,性交前 1h口服西地那非 5 0～ 10 0mg ,2～3日口服 1次 ,连续 4wk ;B组 2 4例 ,同时给予安慰剂治疗 4wk。间隔 1wk后 ,2组用药顺序进行自身前后交叉治疗。采用勃起功能国际问卷 (IIEF 5 )进行评价。结果 :A ,B 2组服用西地那非总有效率分别为 79%与 71% (P >0 .0 5 )。A ,B 2组在交叉服药后 ,其治疗ED总有效率西地那非治疗组为75 % ,而安慰剂组为 2 1% (P <0 .0 5 )。不良反应较轻微而且短暂。结论 :西地那非治疗骨盆骨折尿道损伤后阴茎勃起功能障碍疗效确切 。

AIM: To observe the efficacy and safety of sildenafil in the treatment of erectile dysfunction caused by pelvis trauma and prostato membranous urethral injury. METHODS: A double-blind, placebo-controlled, randomized, two-way crossover clinical trials was undertaken. Fifty-two patients with erectile dysfunction were divided into two groups: twenty-eight patients of group A were treated with sildenafil (50-100 mg, once 2-3 d) and Twenty-four patients of group B received placebo similar to sildenafil for 4 wk. One week later, two groups were conduced a 4 wk crossover treatment. Responses were evaluated by using the International Index for Erectile Function(IIEF) questionnaire after treatment. RESULTS: The total effective rate of sildenafil group (75 %) was superior to that of the placebo group (21 %, P<0.05). The adverse reaction of sildenafil were infrequent and generally mild, similar to that of placebo. CONCLUSION: Sildenafil is effective in treating erectile dysfunction caused by pelvis trauma and prostato membranous urethral injury.