大肠癌根治术后门静脉置泵化疗预防肝转移

PREVENTION OF HEPATIC METASTASIS AFTER RADICAL RESECTION OF COLONIC CARCINOMA WITH CHEMOTHERAPY VIA A PUMP IMPLANTED IN THE PORTAL VEIN

探讨大肠癌根治术后肝转移的预防方法。将 5 4例大肠癌根治术后患者随机分成两组 :A组 (32例)门静脉插管灌注化疗 ,B组(2 2例 )外周静脉化疗。两组病人术前检查术中探查均未发现肝转移灶。结果显示 ,肝转移率A组为 15 4 % (5例 ) ,B组为 36 4 % (8例)。1、2、3年生存率A组分别为 98%、83%、6 1% ,B组为 90 %、6 8%、4 2 %。提示门静脉置泵化疗对预防大肠癌根治术后肝转移有显著意义。

To evaluate the value of chemotherapy via portal vein pump implantation in preventing hepatic metastasis from colorectal cancer after a radical resestion. Patients after a radical resection were divided into two groups: the portal vein pump implantation chemotherapy group (Group A 32 cases), chemotherapy via peripheral vein(Grounp B 22 cases). The results showed that hepatic metastasis rate was 15 4% in group I and 36 4% in group 2. The survival rates of 1, 2, 3 years in group A were 98%, 83%, 61% respectively, while in group B they were 90%, 68%, 42%, respectively. The results suggested that portal vein pump chemotherapy was an effective treatment modality to prevent hepatic metastasis from colorectal cancer. Its clinical results were better than conventional chemotherapy via peripheral vein.