肥胖青少年血清瘦素、胰岛素和胰岛素原水平的变化

The changes in plasma leptin, insulin and proinsulin levels in obese adolescents

目的 检测肥胖青少年血清瘦素、胰岛素、胰岛素原水平的变化 ,探讨青少年肥胖与代谢综合征的关系。方法 从年龄 14～ 16岁的 2 2 17例学生中筛选出体重指数 (BMI)≥ 2 5kg/m2 的肥胖学生 (肥胖组 ) 198例 ,BMI在 18 5～ 2 3 0kg/m2 之间的体重正常学生 (正常组 ) 78例 ,用放射免疫方法测定血清瘦素、胰岛素和胰岛素原水平 ,同时测定血糖及血脂水平 ,比较两组间差异。结果 血清瘦素水平女生明显高于同龄男生 [(18 5 3± 1 4 1) μg/L比 (6 33± 1 79) μg/L]。肥胖组血清瘦素、胰岛素和胰岛素原水平均高于同龄体重正常者 [分别为 (19 94± 1 91) μg/L比 (11 2 7± 2 0 4 ) μg/L ,(15 34± 1 6 6 ) μIU/L比 (13 17± 1 4 3) μIU/L ,(16 19± 1 6 4 )pmol/L比 (11 79± 1 70 )pmol/L ],血糖、甘油三酯 (TG)和高密度脂蛋白胆固醇 (HDL C)水平虽然在正常范围内 ,但肥胖者血糖和TG水平高于同龄体重正常者 [分别为 (4 6 3± 0 5 0 )mmol/L比 (4 13± 0 33)mmol/L ,(1 2 0± 0 5 6 )mmol/L比 (0 90±0 32 )mmol/L],HDL C水平低于同龄体重正常者 [(1 14± 0 2 4 )mmol/L比 (1 38± 0 2 6 )mmol/L]。结论 肥胖青少年可能存在瘦素抵抗、胰岛素抵抗及潜在的糖代谢和脂代谢异常等代谢综合征改变 ,

Objective To investigate the metabolic changes in obese adolescents and the relationship between obese adolescents and metabolic syndrome Methods 198 obese adolescents[body mass index (BMI)≥25 kg/m 2] and 78 normal adolescents (BMI 18 5～23 0 kg/m 2) were chosen from 2 217 middle school students of 14～16 years The levels of serum leptin, insulin, proinsulin, glucose and lipids of these adolescents were measured and compared Results (1) There was significant gender difference of serum leptin levels in adolescents of 14～16 years The level of serum leptin was higher in female than that in male [(18 53±1 41) μg/L vs (6 33±1 79)μg/L] (2) The levels of serum leptin, insulin and proinsulin of obese adolescents were significantly higher than those of normal adolescents [(19 94±1 91) μg/L vs (11 27±2 04) μg/L, (15 34±1 66) μIU/L vs (13 17±1 43) μIU/L and (16 19±1 64) pmol/L vs (11 79±1 70) pmol/L respectively] (3) The levels of blood glucose and triglyceride of obese adolescents were significantly higher than those of normal adolescents [(4 63±0 50) mmol/L vs (4 13±0 33) mmol/L and (1 20±0 56)mmol/L vs (0 90±0 32) mmol/L respectively], but the levels of serum high density lipoprotein cholesterol(HDL C) of obese adolescents were significantly lower than those of normal adolescents [(1 14±0 24)mmol/L vs (1 38±0 26)mmol/L] Conclusion It is suggested that there are leptin resistance, insulin resistance and potential disorders of blood glucose and lipid metabolism in obese adolescents Our study indicated that adolescent obesity would be related with early occurrence of type 2 diabetes