大剂量放化疗加自体骨髓移植治疗实体瘤及恶性血液病

Treatment of Solid Tumor and Malignant Hematologic Disease With High Dose Chemoradiotherapy and Autologustransplantation

目的：评价大剂量放化疗加自体骨髓移植治疗 实体瘤及恶性血液病的疗效及部分影响因素。方法：采集骨髓造血干细胞体外保存５２ｈ待预 处理后回输体内，预处理方案包括ＣＴＸ＋ＴＢＩ，ＣＴＸ＋Ｍｅｌ，ＶＣＲ＋ＣＴＸ＋威猛＋ＡＤＭ等。结果：患者移 植后均重建造血，３例淋巴瘤无病生存７～４６月仍在随访中，２例肺癌及１例卵巢癌ＡＢＭＴ后明显 好转分别５～８月死亡。４例ＡＬ移植后生存７～２４月复发死亡，结论：恶性淋巴瘤疗效更显著， 其它实体瘤也有一定的疗效，急性白血病ＡＢＭＴ明显高于常规化疗。

Objective:To evaluate the effective ness and some influent factors of high dose chemoradiotherapy and autologus rans plantation.Method:Harvested hematopoietic stem cells were reservedin vitro for 5 2 hours and re-transfused after pre-treatment which includes CTX+TBI,CTX+MeL，VC R+CTX+VM26+ADM，etc.Results:Hematopoiesis has been reconstructed in all 10 cases of Which 4 ALs survived 7～24 months,3 cases of lymphoma have had a disease fre e survival of 7～46 months and remain in follow-up,2 cases of lung cancer and 1 case of ovary cancer improved evidently and died in 5～8 months.Conclusion:More effective for lymphoma and has a definite effect for other solid tumors.The cura tive effect of is superior to conventioal chemotherapy for the BMT treatment of acuteeukemia.