高血压病与一氧化氮的研究进展

Advance Research in Relationship between Nitric Qxide and Essential Hypertension

目的：探讨一氧化氮与高血压发生发展的关系 。方法：通过查阅近年国内外大量有关一氧化氮与高血压研究成果的文献。结果：高血压病 人存在内皮依赖性的血管舒张功能障碍，血管内皮合成或释放一氧化氮明显减少，引起高血 压。结论：一氧化氮与高血压的发生、发展有密切关系，纠正血管内皮功能失调为高血压的 治疗提供新的方向。

Objective:To evalate the relationsh ip between nitric oxide and essential hypertension.Methods:According to review a number of related studies domestic and international in the past few years.Resu lts:Patients with essential hypertension have abnormal endothelium-dependent vas cular relaxation.Reduction of nitric oxide synthesized and released by vascular endothelium causes hypertension.Conclusion:Nitric oxide is correlated with the p athogensis and severity of essential hypertension.These findings indicate improv ing impaired vascular endothelium is a new method in treatment of hypertension.