支气管肺泡灌洗液组织多肽抗原检测对肺癌诊断的价值

Determination of TPA in bronchoalveolar lavage fluid for patients with lung cancer

目的 :探讨支气管肺泡灌洗液 (BALF)中组织多肽抗原 (TPA)含量对肺癌的诊断价值。方法 :应用酶联免疫法检测 6 0例初次确诊的肺癌和 30例肺良性疾病患者BALF中TPA含量 ,并与血清中含量比较。采用ROC曲线确定BALF中TPA的阈值。结果 :肺癌患者BALF中TPA含量明显高于肺良性疾病患者 (P <0 .0 5 ) ,BALF中TPA检测诊断肺癌的灵敏度为 83.33% ,特异度为 86 .6 7%。肺癌患者BALF中TPA含量显著高于血清中的含量 (P <0 0 1)。结论

Aim:To investigate the diagnostic value of TPA determination in bronchoalveolar lavage fluid (BALF) for lung cancer.Methods:TPA levels were measured with enzyme linked immunosorbent assay(ELISA)in the BALF of 60 patients with lung cancer and 30 patients with benign lung diseases. The results were compared to those of serum TPA.The threshold value of TPA in BALF were determined by ROC curve.Results:Levels of TPA in BALF in patients with lung cancer were higher than those with benign lung diseases ( P <0 05) The sensitivity and specificity of TPA for diagnosing lung cancer were 83.33% and 86 67%,respectively.TPA levels in BALF in patients with lung cancer were significantly higher than those in serum.Conclusion:Determination of TPA in BALF can be used to diagnose lung cancer.