摘要
目的 :探讨乳癌患者血清肿瘤坏死因子 (TNF)、白细胞介素 2 (IL 2 )、白细胞介素 6 (IL 6 )测定的临床意义。方法 :采用放射免疫分析法对 4 9例乳癌、31例乳腺良性病变患者血清TNF、IL 2、IL 6进行了测定 ,并与 30例健康女性对照。结果 :乳癌组血清TNF、IL 6含量明显高于正常对照组和良性病变组 (P <0 0 1) ;且随着临床分期的增加 ,而逐步升高 ;而IL 2含量则明显低于正常对照组和良性病变组 (P <0 0 1) ,且随病情进展呈降低趋势 ;良性病变组与正常对照组相比 ,TNF、IL 2、IL 6差异无显著性 (P >0 0 5 )。结论 :乳癌患者血清中多种细胞因子存在分泌调节紊乱 ,检测乳癌患者血清TNF、IL 2、IL 6 ,可作为乳癌辅助诊断。
Aim: To study the clinical significance of the test of serum tumor necrosis factor(TNF), interleukine 2(IL 2), and interleukine 6(IL 6) in patients with mastocarcinoma. Methods: The serum TNF, IL 2, and IL 6 in 49 cases of mastocarcinoma, 31 cases of benign disease, and 30 normal women were tested by using radioimmunoassay. Results: The serum TNF and IL 6 for patients with mastocarcinoma were remarkably higher than those of normal group and benign disease group ( P <0 01),and it would continuously increase along with the development of the mastocarcinoma. But the serum IL 2 were obviously lower than those of normal group and benign disease group ( P <0 01), and it would continuously decreased along with the development of the mastocarcinoma. The serum TNF,IL 2 and IL 6 had no remarkable difference between normal group and benign disease group ( P >0 05). Conclustion: Many cell factors have secretion and regulation turbulence in serum for patients with mastocarcinoma. The tests could be reference indexes for diagnosis and prediction for patients with mastocarcinoma.
出处
《郑州大学学报(医学版)》
CAS
北大核心
2002年第2期215-216,共2页
Journal of Zhengzhou University(Medical Sciences)