银屑病患者皮损中磷脂酰肌醇3激酶过表达

Up-regulation of Expression of Phosphatidylinositol 3-kinase in Psoriatic Lesions

目的探讨磷脂酰肌醇3激酶(PI3激酶)与银屑病发病的相关性。方法应用点杂交、原位杂交和免疫组化的方法,分析了12例寻常型银屑病患者皮损区和5例正常人表皮中PI3激酶表达分布特点。结果银屑病皮损中PI3激酶mRNA和蛋白的表达较正常人皮肤明显增强,银屑病患者与正常人皮肤中PI3激酶基因与蛋白的表达一致。结论银屑病皮损中PI3激酶过表达可能与银屑病角质形成细胞的过度增殖相关。

Objective To investigate the correlation between phosphatidylinositol 3 kinase (PI3-kinase) and the pathogenesis of psoriasis. Methods By dot hybridization, in situ hybridization and immunohistochemistry, expression of PI3 kinase was observed in twelve psoriatic and five normal epidermis. Results In psoriatic epidermis, expression of PI3 kinase gene and protein was elevated obviously compared with that of normal skin. Conclusion PI3 kinase may be closely associated with hyperproliferation of psoriatic keratinocytes.