摘要
目的 探讨病毒性脑炎患儿血清、脑脊液中白细胞介素 6 (IL 6 )、白细胞介素 8(IL 8)、肿瘤坏死因子 α(TNF α)水平的变化及其临床意义。方法 采用双抗体夹心酶联免疫法测定 30例病毒性脑炎患儿血清、脑脊液中IL 6、IL 8、TNF α水平 ,并与 15例非中枢神经系统疾病患儿进行对照。结果 血清中的IL 6、IL 8、TNF α的水平高于对照组 (P <0 .0 5 ) ;脑脊液中IL 6、IL 8、TNF α水平较对照组明显升高 (P <0 .0 1)。结论 IL 6、IL 8、TNF α不仅具有抗病毒的作用 。
Objective To study the changes of IL 6? IL 8 and TNF α levels in serum and cerebrospinal fluid (CSF) in children with viral encephalitis.Methods IL 6? IL 8 and TNF α were determined using ELISA in 30 cases with viral encephalitis, and 15 children saved as controls.Results The levels of IL 6? IL 8 and TNF α in serum in children with viral encephalitis were higher than that of the controls ( P< 0.05 );The evels of IL 6? IL 8 and TNF α in CSF in children with viral encephalitis were significantly higher than that of the controls ( P < 0.01 ).Conclusion IL 6? IL 8 and TNF α not only have anti viral effect, but also play a role in pathogenesis of encephalitis in children.
出处
《华中医学杂志》
2002年第2期71-72,共2页
Central China Medical Journal
