慢性肺源性心脏病患者血清内源性洋地黄样因子的临床观察

Clinical Observation of Serum Endogenous Digitalis-like Factor in Chronic Cot Pulmonale

本文用放射免疫方法测定28例慢性肺源性心脏病急性期患者和20例正常人血清EDF 浓度,结果显示:慢性肺源性心脏病组血清 EDF 浓度明显低于正常对照组,P<0.01;随心功能不全程度加重,血清 EDF 浓度明显降低;合并有心房纤颤者血清 EDF 浓度明显低于窦性节律者,P<0.025;血清 EDF 浓度与血红蛋白浓度、右室流出道直径、血清 T_3、T_3浓度呈明显正相关,r 分别为0.5276、0.6242、0.6394、0.6383,P 分别<0.01、<0.01、<0.05、<0.05;慢性肺源性心脏病恢复期患者血清 EDF 浓度较急性期明显升高,P<0.05,但仍低于正常对照组水平,P<0.01。

The determination of serum endogenous digitalis-like factor(EDF)was carriedout in 28 patients with chronic pulmonary heart disease(CPHD)with radioimmuno-assay.The results showed that concentrations of serum EDF in patients with CPHDwere significantly lower than those of normal subjeets(P<0.01).The more severedegree of cardiac insufficiency,the lower the serum EDF concentrations.SerumEDF concentrations of patients with atrial fibrillation were significantly lowerthan those of patients with sinus rhythm(P<0.025).Serum EDF concentrations weresignificantly positively correlated with concentrations of Hb,serum T_3,T_4 and rightventricular output diameter(r=0.5276,0.6242,0.6394,0.6383 respectively;P<0.01,<0.01,<0.05,<0.05 respectively).Serum EDF concentration increased as cardiac func-tion was improved(P<0.05),but still lower than those of normal cases(P<0.01).