肺癌组织中FHIT基因蛋白的表达缺失与吸烟的关系

Loss of FHIT Expression in Lung Cancer and its Correlation with Smoking

[目的]研究脆性组氨酸三联体(FHIT)基因蛋白在肺癌组织中的表达及其与吸烟的关系。[方法]运用免疫组织化学SP法检测56例外科切除的肺癌组织中FHIT蛋白的表达。[结果]56例肺癌组织中33例(58.9%)显示FHIT蛋白缺失。肺鳞癌(SqCCs)中FHIT蛋白缺失率明显高于非鳞癌(non SqCCs)(72.7%vs39.1% ;χ2 =6.32,P=0.012) ;而且吸烟患者中FHIT蛋白缺失率明显高于非吸烟者(67.5%Vs37.5% ;χ2=4.25,P=0.039)。[结论]FHIT蛋白的表达缺失是肺癌中的常发事件 ,尤其在肺鳞癌和吸烟者中。FHIT蛋白的表达可以作为肺癌诊断的一个标志物 。

To investigate the protein expression of Fragile Histidine Triad (FHIT)gene in lung cancer and its correlation with smoking.Fifty-six tumor specimens from surgically resected lung cancer patients were analyzed for expression of FHIT protein by means of SP immunohistochemistry.Thirty-three of 56(58.9%)lung cancer showed loss of FHIT expression.The frequency of loss of FHIT was significantly higher in squamous cell carcinomas (SqCCs)than that in non-SqCCs(72.7% vs 39.1%;χ2=6.32,P=0.012).Moreover,loss of FHIT was observed more frequently in smokers(27 of 40,67.5%)than that in non-smokers(6 of 16,37.5%;χ2=4.25,P=0.039).[Conclusions]Loss of FHIT is a frequent event in lung cancer,particularly in SqCCs and in smokers.These results suggest that FHIT expression could be a useful marker for the diagnosis of lung cancer,and that FHIT could play a role in the smoking-related carcinogenesis of lung cancer.