TRAIL抗癌作用的分子机制

The Mechanisms of a New Type Anti-tumor Molecule──TRAIL

TRAIL是近年新发现的一种凋亡诱导配体 ,它能够选择性地诱导肿瘤细胞凋亡 ,而使正常细胞逃逸其杀伤作用。TRAIL强大的凋亡诱导能力和选择性的杀伤作用 ,引起了广大研究者极大的兴趣。本文从TRAIL的结构功能开始分析 ,论述了TRAIL作用的分子机制 。

TRAIL(TNF related apoptosis inducing ligand)is a newly identified apoptosis inducing ligand.It could selectively induce the apoptosis of tumor cells but spare the normal tissue cells.Its powerful capability of inducing apoptosis and its special selectivity of killing tumor cells have raised the interests of many researchers.Many of researchers have done a lot to find out the mechanism.In this article,we will introduce the general molecular mechanisms of the anti-tumor molecule named TRAIL,which will establish a sound foundation for a further research of TRAIL and for the further application of it in the future.