摘要
随着喉癌、下咽癌研究的深入 ,有关其分子生物学标记物的研究愈来愈多 ,如P53、P16 、CyclinD1、Ki6 7、Bcl - 2及染色体位点等 ,但由于研究方法不同 ,病例数相对较少 ,因此 ,对各种标记物与喉癌、下咽癌临床表现及生物学行为的关系难以作出准确评价。现复习有关文献 ,寻求有价值的分子生物学标记物 ,为喉癌。
参考文献18
-
1Zhang LF, Hemminki K, Szyfter K, et al.P53mutations in larynx cancer[J].Carcinogenesis,1994,15:2929-2951.
-
2Brennan JA, Mao L, Hruban RH,et al.Molecular assessment of histopathological staging in squamous-cell carcinoma of the head and neck[J].N Engl J Med,1995,332:429-435.
-
3Shin DM, Lee JS, Lippman SM, et al.P53expression predict recurrence and second primary tumors in head and neck squamous cell carcinoma[J].J Natl Cancer Inst,1996,88:519-529.
-
4G allo O, Santucci M, Franchi A.Cumulative prognostic value of P16/CDKN2 and p53 oncoprotein expression in premalignant laryngeal lesions[J].J Natl Cancer Inst,1997,89:1161-1163.
-
5Clyman GL, El-Naggar AK, Lippman SM, et al.Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma[J].J Clin Oncol,1998,116:2221-2232.
-
6Kyomoto R, Kumazawa H, Toda Y, et al.Cyclin-Dl gene amplification is a more potent prognostic factor than its protein over-expession in human head and neck squamous-cell carcinoma[J].Int J Cancer,1997,74:576-581.
-
7Cattani P, Hohaus S, Bellacosa A,et al.Association between cyclin D1(CCND1 gene amplification)and human papillomavirus infection in human laryngeal squamous cell carcinoma[J].Clin Cancer Res,1998,4:2585-2598.
-
8Franchi A, Gallo O, Boddi V, et al.Prediction of occult neck metastases in laryngeal carcinoma: Role of prolifieating cell nuclear antigen, MIB-1, and E-cadherin immunohistochemical determination[J].Clin Cancer Res,1996,2: 1801-1808.
-
9Urano M, Iwata S, Takasu A, et al.An immunohistochemical study of proliferating cell nuclar antigen (PCNA) and MIB-1 in epithelial and dysplasia of the vocal chords[J].Nippon Jibiinkoka Gakkai Kaiho, 1995,15(5):1571-1520.
-
10Grandis JR, Melhem MF, Gooding WE, et al.Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival[J].J Natl Cancer Inst,1998,90:823-832.
同被引文献13
-
1Brennan JA,Mao L,Hruban RH,et al.Molecular assessment of histpathological staging in squamous-cell carcinoma of the and neck. The New England Journal of Medicine . 1995
-
2Grandis JR,Meihem MF,Gooding WE.et al.Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival. Journal of National Cancer Institute . 1998
-
3Friendman M,Grey P,Venkatesan TK.et al.Prognostic significance of bcl-2 expression in localized squamous cell carcinoma of thehead and neck. Ann Rhinol laryngeai . 1997
-
4Jin YT,Kayser S.Kemp BL,et al.The prognostic significance of the carcinoma. Cancer . 1998
-
5M Maurizi,G Almadori,G Ferrandina.Prognostic significance of epidermal growth factor receptor in laryngeal squamous cell carcinoma. British Journal of Cancer . 1996
-
6万保罗,董明敏,马季青,贾建,马蒿,谢卫民,董民声.喉癌手术安全切缘的免疫组化研究[J].临床耳鼻咽喉科杂志,1999,13(9):394-396. 被引量：21
-
7凌玲,周敏妤,王辉萼.喉癌EGFR和PCNA表达及DNA含量的研究[J].临床耳鼻咽喉科杂志,2000,14(3):99-101. 被引量：13
-
8张桂茹,王晓明,刘莉.喉癌与喉癌前病变、喉良性病变中PCNA表达的对比及临床意义[J].白求恩医科大学学报,2000,26(4):379-381. 被引量：4
-
9赵明,李野,孙立群,郭丽娟,许亚辉.喉癌组织中P16的免疫组化定量分析[J].白求恩医科大学学报,2000,26(4):382-384. 被引量：3
-
10万福生,曾昭建,张少容,万义福.抑癌基因P16在喉癌中的表达[J].中国肿瘤临床与康复,2000,7(5):32-33. 被引量：4
-
1赵快乐,施学辉,蒋国梁.食管癌预后有关的分子生物学标记物[J].中国癌症杂志,2001,11(3):273-275. 被引量：3
-
2冉飞武,李建彬,于金明.与非小细胞肺癌预后相关的分子生物学标记物的研究现状[J].中国肿瘤临床与康复,2004,11(4):375-378. 被引量：1
-
3李加美,王强修,张珂,林晓燕.甲状腺乳头状癌分子标记物研究进展[J].中华临床医师杂志（电子版）,2012,6(23):7698-7700. 被引量：7
-
4杭小锋,刘玉杉.膀胱移行细胞癌分子生物学标记物研究进展[J].中国肿瘤,2006,15(4):244-247.
-
5朱信信,杨红鹰.三阴性乳腺癌相关分子标记物的表达及临床特征分析[J].诊断病理学杂志,2015,22(1):53-56. 被引量：10
-
6黄二勇.神经母细胞瘤分子生物学标记物与临床预后判定[J].国外医学（儿科学分册）,1999,26(3):135-138.
-
7戴成林,刘会春.胆囊癌分子生物学的研究进展[J].安徽医药,2009,13(5):558-560. 被引量：1
-
8刘丹丹,易永芬,邓玮.maspin、p27、skp2在大肠肿瘤的表达及意义[J].世界华人消化杂志,2006,14(3):267-272. 被引量：5
-
9梁锐,王芳,王开昕,高倩,王志强,杨耘.MAGE-A1,-A4基因在大肠肿瘤中的表达及临床意义[J].世界华人消化杂志,2005,13(5):657-661. 被引量：2
-
10李新燕,王全红.染色体等位基因杂合性丢失与宫颈癌发生的关系[J].肿瘤研究与临床,2005,17(S1):44-48. 被引量：2
