原发性高血压患者红细胞膜 Ca-ATP 酶活性

Eryrthrocyte Membrane Ca-ATPase Activity in Essential Hypertension

本文报告60例原发性高血压患者男44,女16,平均年龄49.2±7.3岁,平均血压(MAP)16.03±1.12kPa(120.2±8.4mmHg)红细胞膜 Ca-ATP 酶活性,以同年龄组60名健康人为对照:男41,女19,平均年龄40.7±13.1岁,MAP12.43±0.63kPa(93.2±4.8mmHg)。结果表明,高血压患者红细胞膜 Ca-ATP 酶活性0.44±0.088μmolPi/mgprot·h^(-1),明显低于对照组0.64±0.052μmol Pi/mg prot·h^(-1),P<0.001。该酶活性变化与 MAP 呈明显负相关。本研究结果提示,质膜 Ca-ATP 酶活性减低对于细胞内游离 Ca^(2+)浓度提高及高血压发病可能起一定的作用。

The activity of Ca-ATPase of erythrocytes was measured in 60 control subjectsand in 60 patients with essential hypertension.The results showed that erythro-cyte Ca-ATPase activity was decreased significantly in hypertensives than incontrol subjects(0.44±0.088 vs 0.64±0.052 μmol Pi/mg prot.h^(-1),mean±SD,P<0.001),an inverse correlation was found between the enzyme activity and mean arte-rial prassure.It indicated that an inhibition of Ca-ATPase activity of plasmamembrane in patients with essential hypertension might play a certain role in Ca^(2+)intracellular accumulation and in pathogenesis of essential hypertension.