急性心肌梗塞患者血TXB_2,6-K-PGF_(1α)水平改变的初步观察

Preliminary Observation on Changes of Plasma TXB_2 and 6-Keto-PGF_(1α) In Patients with Acute Myocardial Infarction

本文报道24例急性心肌梗塞患者发病24小时内血 TXB_2,6-K-PGF_(1α),PRA 和ATⅡ的水平。与正常对照组比较,心梗组血 TXB_2,6-K-PGF_(1α)及 T/P 比值显著增加(P<0.01),提示 TXA_2,PGI_2失衡的致病作用。而 T/P 比值改变可作为防治本病的参考指标。本文还观察到,心梗急性期血清 CPK 水平与血 TXB_2,T/P 比值无相关性(P>0.05),而与6-K-PGF_(1α)呈正相关(P<0.025)。另外,同时测定 PRA,AT Ⅱ表明,在排除开搏通影响后(本文心梗患者中有13例服用开搏通,其血 PRA 较对照组显著升高,P<0.01,ATⅡ降低,P<0.025。11例未服用者血 PRA,ATⅡ均较对照组显著升高,P<0.01),提示心梗急性期肾素——血管紧张素系统活性增加。

The article reported the plasma levels of TXB_2,6-K-PGF_(1α),PRA,and ATⅡ in24 cases were determined within 24 hours after AMI.Compared with controls,thelevels of TXB_2, 6-K-PGF_(1α)and T/P ratio were found significantly increased(P<0.01).It was suggested that imbalance of TXA_2 and PGI_2 was pathogenesis to deve-lop AMI.The change of T/P ratio could be used as an indicator for prevention andtreatment of AMI.It was also showed that the level of serum CPK had no rela-tionship with TXB_2 and T/P ratio(P>0.05),but had positive correlation with6-K-PGF_(1α)(P<0.025).In addition,excluding the influence of Captopril,we demon-strated that the activity of Renin-Angiotensin System was critically increased inthe acutephase of AMI.