系统性红斑狼疮患者系列高凝检测的临床意义

Clinical Significance of Serial Hypercoagulative Assays in Systemic Lupus Erythematosus

系统性红斑狼疮患者易于并发栓塞性血管病变。为探讨其发生机制,本文检测了16例患者的凝血、抗凝及纤溶系统功能的变化。结果表明 SLE 患者与正常对照相比其 PAgT 明显增强(P<0.01);血浆ⅧR:Ag、Fn 浓度显著升高(P<0.01,0.05);APTT 明显延长(P<0.01)。而 ATⅢ:Ag、ATⅢ:C 及 Plg 无明显改变。3例并发血栓栓塞的患者,APTT 皆明显延长,PAgT、ⅧR:Ag 及血浆 Fn 水平都高于正常;而外周血小板计数均严重减少。本研究提示 SLE 患者血小板聚集功能增强、继发性促凝物质(血浆 Fn、ⅧR:Ag)增加而处于一种高凝状态,可能是其易于并发血栓栓塞性疾病的重要原因。

The hypercoagulable indexes in patients with SLE were studied.The resultsshowed that the levels of plasma Ⅷ R:Ag,Fn and PAgT were increased,APTT wasprolonged,and the levels of ATⅢ:Ag,ATⅢ:C and Plg were not changed.In all 3cases with embolie thrombosis,the levels of Fn,PAgT and Ⅷ R:Ag were signifi-cantly higher than the normal limits and peripheral platelet counts were less than80×10~9/L.It was suggested that increased levels of PAgT and plasma Fn and Ⅷ R:Ag were important indexes for the hypercoagulable state in lupus patients.