呋喃苯胺酸抗离体鼠心再灌注损伤作用的研究

The Protective Effect of Furosemide on Myocardial Reperfusion Injury of Isolated Rat Hearts

在Langendorff主动脉逆灌装置上初步发现,呋喃苯胺酸(FRM)对心肌缺血后再灌注损伤具有保护作用。FRM保护组(10um/L)冠脉流量及心肌收缩力的恢复程度优于对照组,再灌注心律失常发生率明显低于对照组。但FRM保护作用的剂量依赖性及其潜在的负性肌力作用等问题尚有待进一步研究。

The protective effect of furosemide (FRM) on myocardial reperfusion injury was studied in isolated rat hearts. The results showed that (1) the recovery extent of coronary flow rate and cardiac contractility was better than that of the control group. (2) The incidence of reperfusion arrhythmias of FRM group was also lower than that of the control group. Whether the protective effect of FRM on reperfusion injury is doseage dependent is needed to be further evaluated.