恶性组织细胞增生症铁蛋白免疫组化定位及其临床意义

Immunohistochemical Localization of Ferritin in Malignant Histiocytosis and Its Clinical Significance

36例恶性组织细胞增生症铁蛋白免疫组化定位表明,恶组瘤细胞铁蛋白阳性率为100％,经图象分析证实,分化较好的瘤细胞铁蛋白含量较高,分化较差的异型组织细胞铁蛋白含量较低(P<0.01)。10例临床确诊为恶组的患者血清铁蛋白含量远高于正常,提示铁蛋白是恶组瘤细胞肿瘤相关抗原。瘤细胞合成并释放铁蛋白是恶组患者血清铁蛋白升高的原因之一,对铁蛋白的定位及血清学检测有助于恶组的诊断,并可能成为恶组复发及缓解的一个指标。

Thirty six cases of malignant histiocytosis (MH) were used to localise the ferritin by immunohistochemical staining.The positivity rate for ferritin in these cases was 100 percent. The results of image analysis showed that the ferritin in the well-differentiated histiocytes was higher than that in the atypical histiocytes (P<0.01). Another 10 patients which were diagnosed as MH showed surprising higher serum ferritin concentration than that in normal. Our data suggest that ferritin is the tumor associated antigen in MH. The synthesis and release of the ferritin by MH tumor cells is the important cause for the high concentration of serum ferritin in patients with MH. The immunohistochemical localization and serum testing for ferritin may be helpful for MH diagnosis and it. also probably became a new target for MH treatment.