巯甲丙脯酸对实验性冠状动脉痉挛致左室功能不全的作用

Effects of Captopril on the CAS-induced Left Ventricular Dysfunction

本文对21只经麦角新硷诱发冠脉痉挛致左室功能不全的犬,随机分痉挛组,治疗组(巯甲丙脯酸5mg/kg),观察心电图,血流动力学,冠脉造影,左室造影,超声心动图,血管紧张素Ⅰ、Ⅱ和心房肽及病理学变化,发现巯甲丙脯酸具有明显的缓解冠脉痉挛,改善左室功能,防止缺血性心律失常等作用。

An animal model of coronary spasm was prepared bv means of intracoronary ergonovine in 21 mongreal dogs which were divided at random into the spasm group and the treatment group(captopril 5mg/kg).ECG, hemodynamic studies,coronary arteriography, left ventricul-ography, colour doppler echocardiogram, quantification of angiotensin Ⅰ, Ⅱ and atrial natriuretic peptide and pathologic studies were carried out in both groups.It was revealed that captopril could expand the coronary arteries, reduce the pulmonary edema, alleviate the ventricular arrythmias and improve the left ventricular function in coronary artery spasm.